Expression of CALY in cancer - Summary - The Human Protein Atlas

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CALY

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CALY
Gene description	Calcyon neuron-specific vesicular protein
Protein class	FDA approved drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (glioma, pancreatic cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Group enriched (adrenal gland, cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear and cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA042283
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable).
Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (glioma, pancreatic cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA042283

GENE INFORMATION
Gene name	CALY (HGNC Symbol)
Synonyms	CALCYON, DRD1IP, NSG3
Description	Calcyon neuron-specific vesicular protein (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a type II single transmembrane protein. It is required for maximal stimulated calcium release after stimulation of purinergic or muscarinic but not beta-adrenergic receptors. The encoded protein interacts with D1 dopamine receptor and may interact with other DA receptor subtypes and/or GPCRs. [provided by RefSeq, Jul 2008]
Chromosome	10
Cytoband	q26.3
Chromosome location (bp)	133324072 - 133336935
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130643 (version 83.38)
Entrez gene	50632
UniProt	Q9NYX4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NYX4
Antibodypedia	CALY antibodies

PROTEIN BROWSER

CALY-001	CALY-004	CALY-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CALY-001 ENSP00000252939 ENST00000252939	Q9NYX4 [Direct mapping] Neuron-specific vesicular protein calcyon Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0005887 [integral component of plasma membrane] GO:0006897 [endocytosis] GO:0007212 [dopamine receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0030659 [cytoplasmic vesicle membrane] GO:0031410 [cytoplasmic vesicle] GO:0032051 [clathrin light chain binding] GO:0032403 [protein complex binding] GO:0045807 [positive regulation of endocytosis] GO:0048268 [clathrin coat assembly] Show all	217 aa 23.4 kDa	No	1
CALY-004 ENSP00000357543 ENST00000368555	Q9NYX4 [Direct mapping] Neuron-specific vesicular protein calcyon Show all	Predicted intracellular proteins FDA approved drug targets Small molecule drugs Show all	GO:0005887 [integral component of plasma membrane] GO:0006897 [endocytosis] GO:0007212 [dopamine receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0030659 [cytoplasmic vesicle membrane] GO:0031410 [cytoplasmic vesicle] GO:0032051 [clathrin light chain binding] GO:0045807 [positive regulation of endocytosis] GO:0048268 [clathrin coat assembly] Show all	158 aa 17.5 kDa	No	0
CALY-005 ENSP00000357546 ENST00000368558	Q9NYX4 [Direct mapping] Neuron-specific vesicular protein calcyon Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0005887 [integral component of plasma membrane] GO:0006897 [endocytosis] GO:0007212 [dopamine receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0030659 [cytoplasmic vesicle membrane] GO:0031410 [cytoplasmic vesicle] GO:0032051 [clathrin light chain binding] GO:0045807 [positive regulation of endocytosis] GO:0048268 [clathrin coat assembly] Show all	124 aa 13.7 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.