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Cytochrome P450, family 2, subfamily E, polypeptide 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008]
MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
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GO:0005506 [iron ion binding] GO:0005737 [cytoplasm] GO:0006805 [xenobiotic metabolic process] GO:0008392 [arachidonic acid epoxygenase activity] GO:0008395 [steroid hydroxylase activity] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0016712 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen] GO:0019373 [epoxygenase P450 pathway] GO:0020037 [heme binding] GO:0042738 [exogenous drug catabolic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0055114 [oxidation-reduction process]
MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
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GO:0005506 [iron ion binding] GO:0005737 [cytoplasm] GO:0006805 [xenobiotic metabolic process] GO:0008392 [arachidonic acid epoxygenase activity] GO:0008395 [steroid hydroxylase activity] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0016712 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen] GO:0019373 [epoxygenase P450 pathway] GO:0020037 [heme binding] GO:0042738 [exogenous drug catabolic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0055114 [oxidation-reduction process]
GO:0005506 [iron ion binding] GO:0005737 [cytoplasm] GO:0006805 [xenobiotic metabolic process] GO:0008392 [arachidonic acid epoxygenase activity] GO:0008395 [steroid hydroxylase activity] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0016712 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen] GO:0019373 [epoxygenase P450 pathway] GO:0020037 [heme binding] GO:0042738 [exogenous drug catabolic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0055114 [oxidation-reduction process]
Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004497 [monooxygenase activity] GO:0005506 [iron ion binding] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0006805 [xenobiotic metabolic process] GO:0008202 [steroid metabolic process] GO:0008392 [arachidonic acid epoxygenase activity] GO:0008395 [steroid hydroxylase activity] GO:0016098 [monoterpenoid metabolic process] GO:0016491 [oxidoreductase activity] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0016709 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen] GO:0016712 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen] GO:0017144 [drug metabolic process] GO:0019373 [epoxygenase P450 pathway] GO:0019825 [oxygen binding] GO:0019899 [enzyme binding] GO:0020037 [heme binding] GO:0042738 [exogenous drug catabolic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0044281 [small molecule metabolic process] GO:0046483 [heterocycle metabolic process] GO:0055114 [oxidation-reduction process]
