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PNPLA7

GENERAL INFORMATION

Gene name

 PNPLA7

Gene description

 Patatin-like phospholipase domain containing 7

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Mainly cytoplasmic expression in all tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA009130
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 PNPLA7 (HGNC Symbol)

Synonyms

 C9orf111, FLJ31318, FLJ43070, FLJ44279, NTE-R1, NTEL1, RP11-48C7.2

Description

 Patatin-like phospholipase domain containing 7 (HGNC Symbol)

Entrez gene summary

 Human patatin-like phospholipases, such as PNPLA7, have been implicated in regulation of adipocyte differentiation and have been induced by metabolic stimuli (Wilson et al., 2006 [PubMed 16799181]).[supplied by OMIM, Jun 2008]

Chromosome

 9

Cytoband

 q34.3

Chromosome location (bp)

 137459953 - 137550534

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000130653 (version 83.38)

Entrez gene

 375775

UniProt

 Q6ZV29 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6ZV29

Antibodypedia

 PNPLA7 antibodies

PROTEIN BROWSER
PNPLA7-007
PNPLA7-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PNPLA7-007
ENSP00000277531
ENST00000277531
Q6ZV29 [Direct mapping]
Patatin-like phospholipase domain-containing protein 7
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0004622 [lysophospholipase activity]
GO:0005765 [lysosomal membrane]
GO:0005783 [endoplasmic reticulum]
GO:0006629 [lipid metabolic process]
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
GO:0031965 [nuclear membrane]
GO:0031966 [mitochondrial membrane]
GO:0032502 [developmental process]
Show all
 1317 aa
145.7 kDa 		No 1
PNPLA7-201
ENSP00000384610
ENST00000406427
Q6ZV29 [Direct mapping]
Patatin-like phospholipase domain-containing protein 7
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0004622 [lysophospholipase activity]
GO:0005765 [lysosomal membrane]
GO:0005783 [endoplasmic reticulum]
GO:0006629 [lipid metabolic process]
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
GO:0031965 [nuclear membrane]
GO:0031966 [mitochondrial membrane]
GO:0032502 [developmental process]
GO:0052689 [carboxylic ester hydrolase activity]
Show all
 1342 aa
148.4 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.