Cell atlas - MNX1 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

MNX1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoli
	Nucleus

Human cell
	Cytosol
	Nucleoli
	Nucleoplasm

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	MNX1
Gene description	Motor neuron and pancreas homeobox 1
Protein class	Cancer-related genes Disease related genes Plasma proteins Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	6
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus. In addition localized to the nucleoli & cytosol.
RNA cell category	Cell line enhanced (RPMI-8226, SCLC-21H, AN3-CA)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved)
Additional location	In addition localized to the Nucleoli (approved), Cytosol (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA071717
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (RPMI-8226, SCLC-21H, AN3-CA) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus. In addition localized to the nucleoli & cytosol.

Main location

Nucleus (approved)

Additional location

Nucleoli (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA071717	HEK 293	Nucleus
	HPA071717	HEK 293	Nucleoli	Intensity
	HPA071717	MCF7	Nucleus
	HPA071717	U-2 OS	Nucleus
			Nucleoli	Intensity
			Cytosol

GENE INFORMATION
Gene name	MNX1 (HGNC Symbol)
Synonyms	HB9, HLXB9, HOXHB9, SCRA1
Description	Motor neuron and pancreas homeobox 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a nuclear protein, which contains a homeobox domain and is a transcription factor. Mutations in this gene result in Currarino syndrome, an autosomic dominant congenital malformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Chromosome	7
Cytoband	q36.3
Chromosome location (bp)	156994051 - 157010651
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130675 (version 83.38)
Entrez gene	3110
UniProt	P50219 (UniProt - Evidence at protein level)
neXtProt	NX_P50219
Antibodypedia	MNX1 antibodies

PROTEIN BROWSER

MNX1-001	MNX1-003	MNX1-004	MNX1-005	MNX1-006	MNX1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MNX1-001 ENSP00000252971 ENST00000252971	P50219 [Direct mapping] Motor neuron and pancreas homeobox protein 1 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001764 [neuron migration] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006959 [humoral immune response] GO:0008045 [motor neuron axon guidance] GO:0009653 [anatomical structure morphogenesis] GO:0009791 [post-embryonic development] GO:0021520 [spinal cord motor neuron cell fate specification] GO:0021675 [nerve development] GO:0021904 [dorsal/ventral neural tube patterning] GO:0021953 [central nervous system neuron differentiation] GO:0030182 [neuron differentiation] GO:0031016 [pancreas development] GO:0031018 [endocrine pancreas development] GO:0043565 [sequence-specific DNA binding] GO:0048667 [cell morphogenesis involved in neuron differentiation] GO:0048812 [neuron projection morphogenesis] GO:0060539 [diaphragm development] GO:0060541 [respiratory system development] Show all	401 aa 40.6 kDa	No	0
MNX1-003 ENSP00000474286 ENST00000479817	S4R3G1 [Direct mapping] Motor neuron and pancreas homeobox protein 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		31 aa 3.2 kDa	No	0
MNX1-004 ENSP00000401158 ENST00000428439	C9K088 [Direct mapping] Motor neuron and pancreas homeobox protein 1 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] Show all	82 aa 9.3 kDa	No	0
MNX1-005 ENSP00000416458 ENST00000425745	C9JFT4 [Direct mapping] Motor neuron and pancreas homeobox protein 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		29 aa 2.8 kDa	No	0
MNX1-006 ENSP00000475129 ENST00000469500	S4R464 [Direct mapping] Motor neuron and pancreas homeobox protein 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		36 aa 3.5 kDa	No	0
MNX1-201 ENSP00000438552 ENST00000543409	P50219 [Direct mapping] Motor neuron and pancreas homeobox protein 1 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006959 [humoral immune response] GO:0009653 [anatomical structure morphogenesis] GO:0021520 [spinal cord motor neuron cell fate specification] GO:0031018 [endocrine pancreas development] GO:0043565 [sequence-specific DNA binding] GO:0048812 [neuron projection morphogenesis] Show all	189 aa 20.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.