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EXOSC2

GENERAL INFORMATION

Gene name

 EXOSC2

Gene description

 Exosome component 2

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA021790
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and endometrial cancer (unfavourable).
Liver cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA021790

GENE INFORMATION

Gene name

 EXOSC2 (HGNC Symbol)

Synonyms

 hRrp4p, p7, RRP4, Rrp4p

Description

 Exosome component 2 (HGNC Symbol)

Entrez gene summary

Chromosome

 9

Cytoband

 q34.12

Chromosome location (bp)

 130693721 - 130704894

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000130713 (version 83.38)

Entrez gene

 23404

UniProt

 Q13868 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13868

Antibodypedia

 EXOSC2 antibodies

PROTEIN BROWSER
EXOSC2-001
EXOSC2-002
EXOSC2-003
EXOSC2-005
EXOSC2-006
EXOSC2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EXOSC2-001
ENSP00000361433
ENST00000372358
Q13868 [Direct mapping]
Exosome complex component RRP4
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000175 [3'-5'-exoribonuclease activity]
GO:0000176 [nuclear exosome (RNase complex)]
GO:0000177 [cytoplasmic exosome (RNase complex)]
GO:0000178 [exosome (RNase complex)]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000467 [exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006364 [rRNA processing]
GO:0008312 [7S RNA binding]
GO:0010467 [gene expression]
GO:0030307 [positive regulation of cell growth]
GO:0034427 [nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5']
GO:0034475 [U4 snRNA 3'-end processing]
GO:0043488 [regulation of mRNA stability]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
GO:0071034 [CUT catabolic process]
GO:0071035 [nuclear polyadenylation-dependent rRNA catabolic process]
GO:0071038 [nuclear polyadenylation-dependent tRNA catabolic process]
GO:0071049 [nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription]
GO:0071051 [polyadenylation-dependent snoRNA 3'-end processing]
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 293 aa
32.8 kDa 		No 0
EXOSC2-002
ENSP00000361426
ENST00000372351
Q13868 [Direct mapping]
Exosome complex component RRP4
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000175 [3'-5'-exoribonuclease activity]
GO:0000176 [nuclear exosome (RNase complex)]
GO:0000177 [cytoplasmic exosome (RNase complex)]
GO:0000178 [exosome (RNase complex)]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000467 [exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006364 [rRNA processing]
GO:0008312 [7S RNA binding]
GO:0010467 [gene expression]
GO:0030307 [positive regulation of cell growth]
GO:0034427 [nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5']
GO:0034475 [U4 snRNA 3'-end processing]
GO:0043488 [regulation of mRNA stability]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
GO:0071034 [CUT catabolic process]
GO:0071035 [nuclear polyadenylation-dependent rRNA catabolic process]
GO:0071038 [nuclear polyadenylation-dependent tRNA catabolic process]
GO:0071049 [nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription]
GO:0071051 [polyadenylation-dependent snoRNA 3'-end processing]
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 263 aa
29.4 kDa 		No 0
EXOSC2-003
ENSP00000418463
ENST00000495699
A3KFL5 [Direct mapping]
Exosome complex component RRP4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000176 [nuclear exosome (RNase complex)]
GO:0000177 [cytoplasmic exosome (RNase complex)]
GO:0000467 [exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)]
GO:0003723 [RNA binding]
GO:0034427 [nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5']
GO:0034475 [U4 snRNA 3'-end processing]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
GO:0071034 [CUT catabolic process]
GO:0071035 [nuclear polyadenylation-dependent rRNA catabolic process]
GO:0071038 [nuclear polyadenylation-dependent tRNA catabolic process]
GO:0071049 [nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription]
GO:0071051 [polyadenylation-dependent snoRNA 3'-end processing]
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 237 aa
26.3 kDa 		No 0
EXOSC2-005
ENSP00000361425
ENST00000372350
A3KFL1 [Direct mapping]
Exosome complex component RRP4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000176 [nuclear exosome (RNase complex)]
GO:0000177 [cytoplasmic exosome (RNase complex)]
GO:0000467 [exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)]
GO:0003723 [RNA binding]
GO:0034427 [nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5']
GO:0034475 [U4 snRNA 3'-end processing]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
GO:0071034 [CUT catabolic process]
GO:0071035 [nuclear polyadenylation-dependent rRNA catabolic process]
GO:0071038 [nuclear polyadenylation-dependent tRNA catabolic process]
GO:0071049 [nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription]
GO:0071051 [polyadenylation-dependent snoRNA 3'-end processing]
Show all
 200 aa
22.1 kDa 		No 0
EXOSC2-006
ENSP00000361427
ENST00000372352
A3KFL2 [Direct mapping]
Exosome complex component RRP4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000176 [nuclear exosome (RNase complex)]
GO:0000177 [cytoplasmic exosome (RNase complex)]
GO:0000467 [exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)]
GO:0003723 [RNA binding]
GO:0034427 [nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5']
GO:0034475 [U4 snRNA 3'-end processing]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
GO:0071034 [CUT catabolic process]
GO:0071035 [nuclear polyadenylation-dependent rRNA catabolic process]
GO:0071038 [nuclear polyadenylation-dependent tRNA catabolic process]
GO:0071049 [nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription]
GO:0071051 [polyadenylation-dependent snoRNA 3'-end processing]
Show all
 285 aa
32 kDa 		No 0
EXOSC2-201
ENSP00000444917
ENST00000546165
Q13868 [Direct mapping]
Exosome complex component RRP4
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000175 [3'-5'-exoribonuclease activity]
GO:0000176 [nuclear exosome (RNase complex)]
GO:0000177 [cytoplasmic exosome (RNase complex)]
GO:0000178 [exosome (RNase complex)]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000467 [exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006364 [rRNA processing]
GO:0008312 [7S RNA binding]
GO:0010467 [gene expression]
GO:0030307 [positive regulation of cell growth]
GO:0034427 [nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5']
GO:0034475 [U4 snRNA 3'-end processing]
GO:0043488 [regulation of mRNA stability]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
GO:0071034 [CUT catabolic process]
GO:0071035 [nuclear polyadenylation-dependent rRNA catabolic process]
GO:0071038 [nuclear polyadenylation-dependent tRNA catabolic process]
GO:0071049 [nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription]
GO:0071051 [polyadenylation-dependent snoRNA 3'-end processing]
Show all
 267 aa
30 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.