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EIF2S3

GENERAL INFORMATION

Gene name

 EIF2S3

Gene description

 Eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB012471
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 EIF2S3 (HGNC Symbol)

Synonyms

 EIF2, EIF2G, EIF2gamma

Description

 Eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is the largest subunit of a heterotrimeric GTP-binding protein involved in the recruitment of methionyl-tRNA(i) to the 40 S ribosomal subunit. [provided by RefSeq, Jan 2010]

Chromosome

 X

Cytoband

 p22.11

Chromosome location (bp)

 24054716 - 24077971

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000130741 (version 83.38)

Entrez gene

 1968

UniProt

 P41091 (UniProt - Evidence at protein level)

neXtProt

 NX_P41091

Antibodypedia

 EIF2S3 antibodies

PROTEIN BROWSER
EIF2S3-001
EIF2S3-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EIF2S3-001
ENSP00000253039
ENST00000253039
P41091 [Direct mapping]
Eukaryotic translation initiation factor 2 subunit 3
A0A024RBY4 [Target identity:100%; Query identity:100%]
Eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa, isoform CRA_a
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001731 [formation of translation preinitiation complex]
GO:0003743 [translation initiation factor activity]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0008135 [translation factor activity, RNA binding]
GO:0010467 [gene expression]
GO:0044267 [cellular protein metabolic process]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
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 472 aa
51.1 kDa 		No 0
EIF2S3-002
ENSP00000391383
ENST00000423068
H7BZU1 [Direct mapping]
Eukaryotic translation initiation factor 2 subunit 3
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   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0008152 [metabolic process]
Show all
 183 aa
19.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.