Expression of ZC3H4 in cancer - Summary

GENERAL INFORMATION
Gene name	ZC3H4
Gene description	Zinc finger CCCH-type containing 4
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Predominant nuclear expression which in some tissues was combined with cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA040934 , HPA041068
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable).
Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA040934	HPA041068

GENE INFORMATION
Gene name	ZC3H4 (HGNC Symbol)
Synonyms	C19orf7, KIAA1064
Description	Zinc finger CCCH-type containing 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a family of CCCH (C-x8-C-x5-C-x3-H type) zinc finger domain-containing proteins. These zinc finger domains, which coordinate zinc finger binding and are characterized by three cysteine residues and one histidine residue, are nucleic acid-binding. Other family members are known to function in post-transcriptional regulation. [provided by RefSeq, Aug 2011]
Chromosome	19
Cytoband	q13.32
Chromosome location (bp)	47064187 - 47113752
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130749 (version 83.38)
Entrez gene	23211
UniProt	Q9UPT8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UPT8
Antibodypedia	ZC3H4 antibodies

PROTEIN BROWSER

ZC3H4-001	ZC3H4-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZC3H4-001 ENSP00000253048 ENST00000253048	Q9UPT8 [Direct mapping] Zinc finger CCCH domain-containing protein 4 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0044822 [poly(A) RNA binding] GO:0046872 [metal ion binding] Show all	1303 aa 140.3 kDa	No	0
ZC3H4-004 ENSP00000469684 ENST00000601973	M0QY97 [Direct mapping] Zinc finger CCCH domain-containing protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0046872 [metal ion binding] Show all	910 aa 95.4 kDa	No	0