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GMFG

GENERAL INFORMATION

Gene name

 GMFG

Gene description

 Glia maturation factor, gamma

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HMC-1, REH, THP-1)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 RNA-based expert annotation gave inconclusive results.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining not consistent with RNA expression data. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.

Reliability score

 Uncertain based on 1 antibody.
HPA002954
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and cervical cancer (favourable).
Renal cancer p<0.001
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA002954

GENE INFORMATION

Gene name

 GMFG

Synonyms

Description

 Glia maturation factor, gamma (HGNC Symbol)

Entrez gene summary

Chromosome

 19

Cytoband

 q13.2

Chromosome location (bp)

 39328353 - 39342372

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000130755 (version 83.38)

Entrez gene

 9535

UniProt

 O60234 (UniProt - Evidence at protein level)

neXtProt

 NX_O60234

Antibodypedia

 GMFG antibodies

PROTEIN BROWSER
GMFG-001
GMFG-002
GMFG-004
GMFG-005
GMFG-006
GMFG-007
GMFG-010
GMFG-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GMFG-001
ENSP00000472249
ENST00000597595
O60234 [Direct mapping]
Glia maturation factor gamma
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003779 [actin binding]
GO:0004860 [protein kinase inhibitor activity]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0008047 [enzyme activator activity]
GO:0008083 [growth factor activity]
GO:0034316 [negative regulation of Arp2/3 complex-mediated actin nucleation]
GO:0043085 [positive regulation of catalytic activity]
GO:0071933 [Arp2/3 complex binding]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
GO:2000249 [regulation of actin cytoskeleton reorganization]
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 142 aa
16.8 kDa 		No 0
GMFG-002
ENSP00000469877
ENST00000598034
M0QYJ8 [Direct mapping]
Glia maturation factor gamma
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005622 [intracellular]
GO:0034316 [negative regulation of Arp2/3 complex-mediated actin nucleation]
GO:0071933 [Arp2/3 complex binding]
GO:2000249 [regulation of actin cytoskeleton reorganization]
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 138 aa
16.1 kDa 		No 0
GMFG-004
ENSP00000468894
ENST00000594700
M0QX47 [Direct mapping]
Glia maturation factor gamma
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0034316 [negative regulation of Arp2/3 complex-mediated actin nucleation]
GO:0071933 [Arp2/3 complex binding]
GO:2000249 [regulation of actin cytoskeleton reorganization]
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 73 aa
8.8 kDa 		No 0
GMFG-005
ENSP00000253054
ENST00000253054
M0R0C1 [Direct mapping]
Glia maturation factor gamma
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005622 [intracellular]
GO:0034316 [negative regulation of Arp2/3 complex-mediated actin nucleation]
GO:0071933 [Arp2/3 complex binding]
GO:2000249 [regulation of actin cytoskeleton reorganization]
Show all
 109 aa
13 kDa 		No 0
GMFG-006
ENSP00000469050
ENST00000595636
M0QXC2 [Direct mapping]
Glia maturation factor gamma
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005622 [intracellular]
GO:0034316 [negative regulation of Arp2/3 complex-mediated actin nucleation]
GO:0071933 [Arp2/3 complex binding]
GO:2000249 [regulation of actin cytoskeleton reorganization]
Show all
 79 aa
9.3 kDa 		No 0
GMFG-007
ENSP00000471786
ENST00000601387
M0R1D2 [Direct mapping]
Glia maturation factor gamma
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005622 [intracellular]
GO:0034316 [negative regulation of Arp2/3 complex-mediated actin nucleation]
GO:0071933 [Arp2/3 complex binding]
GO:2000249 [regulation of actin cytoskeleton reorganization]
Show all
 101 aa
12 kDa 		No 0
GMFG-010
ENSP00000469813
ENST00000602185
M0QYG8 [Direct mapping]
Glia maturation factor gamma
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005622 [intracellular]
GO:0034316 [negative regulation of Arp2/3 complex-mediated actin nucleation]
GO:0071933 [Arp2/3 complex binding]
GO:2000249 [regulation of actin cytoskeleton reorganization]
Show all
 93 aa
11 kDa 		No 0
GMFG-012
ENSP00000471139
ENST00000600322
M0R0C1 [Direct mapping]
Glia maturation factor gamma
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005622 [intracellular]
GO:0034316 [negative regulation of Arp2/3 complex-mediated actin nucleation]
GO:0071933 [Arp2/3 complex binding]
GO:2000249 [regulation of actin cytoskeleton reorganization]
Show all
 109 aa
13 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.