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Strong cytoplasmic staining was observed in several skin cancers. Most malignant lymphomas along with several urothelial cancers were moderately stained. Remaining malignancies were in general weakly stained or negative.
GENE INFORMATION
Gene name
MAP3K10 (HGNC Symbol)
Synonyms
MEKK10, MLK2, MST
Description
Mitogen-activated protein kinase kinase kinase 10 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. [provided by RefSeq, Jul 2008]