Fields »
ABOUT
HELP
BLOG
CLIP1

GENERAL INFORMATION

Gene name

 CLIP1

Gene description

 CAP-GLY domain containing linker protein 1

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 12
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA026678 , CAB004399
SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA026678
CAB004399

GENE INFORMATION

Gene name

 CLIP1 (HGNC Symbol)

Synonyms

 CLIP, CLIP-170, CLIP170, CYLN1, RSN

Description

 CAP-GLY domain containing linker protein 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Chromosome

 12

Cytoband

 q24.31

Chromosome location (bp)

 122271432 - 122422632

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000130779 (version 83.38)

Entrez gene

 6249

UniProt

 P30622 (UniProt - Evidence at protein level)

neXtProt

 NX_P30622

Antibodypedia

 CLIP1 antibodies

PROTEIN BROWSER
«
CLIP1-001
CLIP1-002
CLIP1-003
CLIP1-005
CLIP1-006
CLIP1-007
CLIP1-008
CLIP1-015
CLIP1-016
CLIP1-017
CLIP1-201
CLIP1-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CLIP1-001
ENSP00000303585
ENST00000302528
P30622 [Direct mapping]
CAP-Gly domain-containing linker protein 1
A0A024RBR1 [Target identity:100%; Query identity:100%]
Restin (Reed-Steinberg cell-expressed intermediate filament-associated protein), isoform CRA_b
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0001578 [microtubule bundle formation]
GO:0001726 [ruffle]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005882 [intermediate filament]
GO:0007067 [mitotic nuclear division]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008017 [microtubule binding]
GO:0008270 [zinc ion binding]
GO:0015630 [microtubule cytoskeleton]
GO:0015631 [tubulin binding]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0035371 [microtubule plus-end]
GO:0042803 [protein homodimerization activity]
GO:0044354 [macropinosome]
GO:0046872 [metal ion binding]
GO:0051010 [microtubule plus-end binding]
Show all
 1427 aa
161 kDa 		No 0
CLIP1-002
ENSP00000445531
ENST00000537178
P30622 [Direct mapping]
CAP-Gly domain-containing linker protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0001578 [microtubule bundle formation]
GO:0001726 [ruffle]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005882 [intermediate filament]
GO:0007067 [mitotic nuclear division]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008017 [microtubule binding]
GO:0008270 [zinc ion binding]
GO:0015630 [microtubule cytoskeleton]
GO:0015631 [tubulin binding]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0035371 [microtubule plus-end]
GO:0042803 [protein homodimerization activity]
GO:0044354 [macropinosome]
GO:0046872 [metal ion binding]
GO:0051010 [microtubule plus-end binding]
Show all
 1392 aa
156.8 kDa 		No 0
CLIP1-003
ENSP00000439093
ENST00000540338
P30622 [Direct mapping]
CAP-Gly domain-containing linker protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0001578 [microtubule bundle formation]
GO:0001726 [ruffle]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005882 [intermediate filament]
GO:0007067 [mitotic nuclear division]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008017 [microtubule binding]
GO:0008270 [zinc ion binding]
GO:0015630 [microtubule cytoskeleton]
GO:0015631 [tubulin binding]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0035371 [microtubule plus-end]
GO:0042803 [protein homodimerization activity]
GO:0044354 [macropinosome]
GO:0046872 [metal ion binding]
GO:0051010 [microtubule plus-end binding]
Show all
 1438 aa
162.2 kDa 		No 0
CLIP1-005
ENSP00000437786
ENST00000540304
F5H6A0 [Direct mapping]
CAP-Gly domain-containing linker protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 803 aa
89.6 kDa 		No 0
CLIP1-006
ENSP00000441409
ENST00000537004
F6VGP8 [Direct mapping]
CAP-Gly domain-containing linker protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 428 aa
46.2 kDa 		No 0
CLIP1-007
ENSP00000355314
ENST00000361654
J3KP58 [Direct mapping]
CAP-Gly domain-containing linker protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005737 [cytoplasm]
GO:0008270 [zinc ion binding]
GO:0035371 [microtubule plus-end]
Show all
 1316 aa
148.1 kDa 		No 0
CLIP1-008
ENSP00000438743
ENST00000545889
F5H0N7 [Direct mapping]
CAP-Gly domain-containing linker protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005737 [cytoplasm]
GO:0008270 [zinc ion binding]
GO:0035371 [microtubule plus-end]
Show all
 1013 aa
116.3 kDa 		No 0
CLIP1-015
ENSP00000437617
ENST00000540539
F5H6H4 [Direct mapping]
CAP-Gly domain-containing linker protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0008270 [zinc ion binding]
Show all
 117 aa
13.5 kDa 		No 0
CLIP1-016
ENSP00000445387
ENST00000539080
F5H367 [Direct mapping]
CAP-Gly domain-containing linker protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 83 aa
8.9 kDa 		No 0
CLIP1-017
ENSP00000439472
ENST00000535290
F5H270 [Direct mapping]
CAP-Gly domain-containing linker protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
 108 aa
11.5 kDa 		No 0
CLIP1-201
ENSP00000351665
ENST00000358808
P30622 [Direct mapping]
CAP-Gly domain-containing linker protein 1
A0A024RBR1 [Target identity:100%; Query identity:100%]
Restin (Reed-Steinberg cell-expressed intermediate filament-associated protein), isoform CRA_b
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0001578 [microtubule bundle formation]
GO:0001726 [ruffle]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005882 [intermediate filament]
GO:0007067 [mitotic nuclear division]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008017 [microtubule binding]
GO:0008270 [zinc ion binding]
GO:0015630 [microtubule cytoskeleton]
GO:0015631 [tubulin binding]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0035371 [microtubule plus-end]
GO:0042803 [protein homodimerization activity]
GO:0044354 [macropinosome]
GO:0046872 [metal ion binding]
GO:0051010 [microtubule plus-end binding]
Show all
 1427 aa
161 kDa 		No 0
CLIP1-202
ENSP00000479322
ENST00000620786
P30622 [Direct mapping]
CAP-Gly domain-containing linker protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0001578 [microtubule bundle formation]
GO:0001726 [ruffle]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005881 [cytoplasmic microtubule]
GO:0005882 [intermediate filament]
GO:0007067 [mitotic nuclear division]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008017 [microtubule binding]
GO:0008270 [zinc ion binding]
GO:0015630 [microtubule cytoskeleton]
GO:0015631 [tubulin binding]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0035371 [microtubule plus-end]
GO:0042803 [protein homodimerization activity]
GO:0044354 [macropinosome]
GO:0044861 [protein transport into plasma membrane raft]
GO:0046872 [metal ion binding]
GO:0051010 [microtubule plus-end binding]
Show all
 1438 aa
162.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.