Expression of HIP1R in cancer - Summary

GENERAL INFORMATION
Gene name	HIP1R
Gene description	Huntingtin interacting protein 1 related
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression combined with membranous expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 3 antibodies. HPA038135 , HPA038136 , CAB017187
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and urothelial cancer (favourable).
Renal cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA038135	HPA038136	CAB017187

GENE INFORMATION
Gene name	HIP1R (HGNC Symbol)
Synonyms	FLJ14000, HIP12, HIP3, ILWEQ, KIAA0655
Description	Huntingtin interacting protein 1 related (HGNC Symbol)
Entrez gene summary
Chromosome	12
Cytoband	q24.31
Chromosome location (bp)	122834453 - 122862960
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130787 (version 83.38)
Entrez gene	9026
UniProt	O75146 (UniProt - Evidence at protein level)
neXtProt	NX_O75146
Antibodypedia	HIP1R antibodies

PROTEIN BROWSER

HIP1R-001	HIP1R-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HIP1R-001 ENSP00000253083 ENST00000253083	O75146 [Direct mapping] Huntingtin-interacting protein 1-related protein Show all	Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005905 [coated pit] GO:0006898 [receptor-mediated endocytosis] GO:0006915 [apoptotic process] GO:0016020 [membrane] GO:0030136 [clathrin-coated vesicle] GO:0030276 [clathrin binding] GO:0030665 [clathrin-coated vesicle membrane] GO:0035091 [phosphatidylinositol binding] GO:0043231 [intracellular membrane-bounded organelle] GO:0048471 [perinuclear region of cytoplasm] GO:0072583 [clathrin-mediated endocytosis] Show all	1068 aa 119.4 kDa	No	0
HIP1R-010 ENSP00000446236 ENST00000535012	H0YH66 [Direct mapping] Huntingtin-interacting protein 1-related protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005905 [coated pit] GO:0006915 [apoptotic process] GO:0030136 [clathrin-coated vesicle] GO:0030276 [clathrin binding] GO:0035091 [phosphatidylinositol binding] GO:0072583 [clathrin-mediated endocytosis] Show all	197 aa 21.7 kDa	No	0