Expression of PNCK in cancer - Summary - The Human Protein Atlas

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PNCK

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PNCK
Gene description	Pregnancy up-regulated nonubiquitous CaM kinase
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	14
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (renal cancer)
HPA (cell line):	Cell line enriched (AN3-CA)
HPA (normal tissue):	Tissue enhanced (cerebral cortex, seminal vesicle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic and nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA007458
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (renal cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA007458

GENE INFORMATION
Gene name	PNCK (HGNC Symbol)
Synonyms	CaMK1b, MGC45419
Description	Pregnancy up-regulated nonubiquitous CaM kinase (HGNC Symbol)
Entrez gene summary	PNCK is a member of the calcium/calmodulin-dependent protein kinase family of protein serine/threonine kinases (see CAMK1; MIM 604998) (Gardner et al., 2000 [PubMed 10673339]).[supplied by OMIM, Mar 2008]
Chromosome	X
Cytoband	q28
Chromosome location (bp)	153669730 - 153689010
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130822 (version 83.38)
Entrez gene	139728
UniProt	Q6P2M8 (UniProt - Evidence at transcript level)
neXtProt	NX_Q6P2M8
Antibodypedia	PNCK antibodies

PROTEIN BROWSER

PNCK-001	PNCK-002	PNCK-004	PNCK-005	PNCK-006	PNCK-013	PNCK-014	PNCK-016	PNCK-019	PNCK-022	PNCK-025	PNCK-026	PNCK-030	PNCK-031

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PNCK-001 ENSP00000359169 ENST00000370150	Q6P2M8 [Direct mapping] Calcium/calmodulin-dependent protein kinase type 1B Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] Show all	343 aa 38.5 kDa	No	0
PNCK-002 ENSP00000359161 ENST00000370142	Q6P2M8 [Direct mapping] Calcium/calmodulin-dependent protein kinase type 1B Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] Show all	366 aa 40.8 kDa	No	0
PNCK-004 ENSP00000405950 ENST00000447676	Q6P2M8 [Direct mapping] Calcium/calmodulin-dependent protein kinase type 1B Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] Show all	426 aa 47 kDa	No	0
PNCK-005 ENSP00000415770 ENST00000439087	C9JJ18 [Direct mapping] Calcium/calmodulin-dependent protein kinase type 1B Show all	MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	226 aa 25 kDa	No	0
PNCK-006 ENSP00000340586 ENST00000340888	Q6P2M8 [Direct mapping] Calcium/calmodulin-dependent protein kinase type 1B Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] Show all	343 aa 38.5 kDa	No	0
PNCK-013 ENSP00000396128 ENST00000434652	C9JEC5 [Direct mapping] Calcium/calmodulin-dependent protein kinase type 1B Show all	Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	86 aa 9.5 kDa	No	0
PNCK-014 ENSP00000391772 ENST00000422811	C9JB09 [Direct mapping] Calcium/calmodulin-dependent protein kinase type 1B Show all	MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	224 aa 24.7 kDa	No	0
PNCK-016 ENSP00000411267 ENST00000418241	C9J8P0 [Direct mapping] Calcium/calmodulin-dependent protein kinase type 1B Show all	Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	94 aa 10.4 kDa	No	0
PNCK-019 ENSP00000390812 ENST00000438984	H7BZQ5 [Direct mapping] Calcium/calmodulin-dependent protein kinase type 1B Show all	Predicted intracellular proteins Show all		81 aa 8.8 kDa	No	0
PNCK-022 ENSP00000359164 ENST00000370145	Q6P2M8 [Direct mapping] Calcium/calmodulin-dependent protein kinase type 1B Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] Show all	360 aa 40.4 kDa	No	0
PNCK-025 ENSP00000395360 ENST00000423545	C9J2B9 [Direct mapping] Calcium/calmodulin-dependent protein kinase type 1B Show all	Predicted intracellular proteins Show all		43 aa 4.8 kDa	No	0
PNCK-026 ENSP00000401542 ENST00000458354	C9J2B9 [Direct mapping] Calcium/calmodulin-dependent protein kinase type 1B Show all	Predicted intracellular proteins Show all		43 aa 4.8 kDa	No	0
PNCK-030 ENSP00000407173 ENST00000425526	C9J2B9 [Direct mapping] Calcium/calmodulin-dependent protein kinase type 1B Show all	Predicted intracellular proteins Show all		43 aa 4.8 kDa	No	0
PNCK-031 ENSP00000400671 ENST00000419804	C9J2B9 [Direct mapping] Calcium/calmodulin-dependent protein kinase type 1B Show all	Predicted intracellular proteins Show all		43 aa 4.8 kDa	No	0

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