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A few cases of hepatocellular carcinomas, breast and urothelial cancers showed moderate cytoplasmic staining. Other cancer tissues were weakly stained or negative.
GENE INFORMATION
Gene name
DUSP9 (HGNC Symbol)
Synonyms
MKP-4, MKP4
Description
Dual specificity phosphatase 9 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases, is expressed only in placenta, kidney, and fetal liver, and is localized to the cytoplasm and nucleus. [provided by RefSeq, Jul 2008]
Q99956 [Direct mapping] Dual specificity protein phosphatase 9
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Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)