Expression of NOL11 in cancer - Summary - The Human Protein Atlas

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NOL11

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NOL11
Gene description	Nucleolar protein 11
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nucleolar expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA022010
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (favourable) and liver cancer (unfavourable).
Colorectal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA022010

GENE INFORMATION
Gene name	NOL11 (HGNC Symbol)
Synonyms	DKFZP586L0724
Description	Nucleolar protein 11 (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	q24.2
Chromosome location (bp)	67717833 - 67744531
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130935 (version 83.38)
Entrez gene	25926
UniProt	Q9H8H0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H8H0
Antibodypedia	NOL11 antibodies

PROTEIN BROWSER

NOL11-001	NOL11-004	NOL11-009	NOL11-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NOL11-001 ENSP00000253247 ENST00000253247	Q9H8H0 [Direct mapping] Nucleolar protein 11 Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006351 [transcription, DNA-templated] GO:0030490 [maturation of SSU-rRNA] GO:0034455 [t-UTP complex] GO:0044822 [poly(A) RNA binding] GO:1901838 [positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter] Show all	719 aa 81.1 kDa	No	0
NOL11-004 ENSP00000463662 ENST00000581106	J3QLQ6 [Direct mapping] Nucleolar protein 11 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005730 [nucleolus] Show all	189 aa 21.3 kDa	No	0
NOL11-009 ENSP00000464015 ENST00000580833	J3QR28 [Direct mapping] Nucleolar protein 11 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] Show all	271 aa 30.5 kDa	No	0
NOL11-010 ENSP00000463248 ENST00000583021	J3QKV1 [Direct mapping] Nucleolar protein 11 Show all	Phobius predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		85 aa 9.6 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.