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RGN

GENERAL INFORMATION

Gene name

 RGN

Gene description

 Regucalcin

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (liver cancer)
HPA (cell line):Group enriched (CACO-2, Hep G2)
HPA (normal tissue):Tissue enhanced (adrenal gland, liver)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in hepatocytes, exocrine pancreas, renal tubules and adrenal cortex.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA029102 , HPA029103
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and liver cancer (favourable).
Renal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA029102
HPA029103

GENE INFORMATION

Gene name

 RGN (HGNC Symbol)

Synonyms

 RC, SMP30

Description

 Regucalcin (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a highly conserved, calcium-binding protein, that is preferentially expressed in the liver and kidney. It may have an important role in calcium homeostasis. Studies in rat indicate that this protein may also play a role in aging, as it shows age-associated down-regulation. This gene is part of a gene cluster on chromosome Xp11.3-Xp11.23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Chromosome

 X

Cytoband

 p11.3

Chromosome location (bp)

 47078355 - 47093314

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000130988 (version 83.38)

Entrez gene

 9104

UniProt

 Q15493 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15493

Antibodypedia

 RGN antibodies

PROTEIN BROWSER
RGN-001
RGN-002
RGN-201
RGN-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RGN-001
ENSP00000253303
ENST00000352078
Q15493 [Direct mapping]
Regucalcin
V9HWF8 [Target identity:100%; Query identity:100%]
Epididymis secretory protein Li 41
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004341 [gluconolactonase activity]
GO:0005509 [calcium ion binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006874 [cellular calcium ion homeostasis]
GO:0008270 [zinc ion binding]
GO:0030234 [enzyme regulator activity]
GO:0032781 [positive regulation of ATPase activity]
GO:0050848 [regulation of calcium-mediated signaling]
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 299 aa
33.3 kDa 		No 0
RGN-002
ENSP00000338400
ENST00000336169
Q15493 [Direct mapping]
Regucalcin
V9HWF8 [Target identity:100%; Query identity:100%]
Epididymis secretory protein Li 41
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004341 [gluconolactonase activity]
GO:0005509 [calcium ion binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006874 [cellular calcium ion homeostasis]
GO:0008270 [zinc ion binding]
GO:0030234 [enzyme regulator activity]
GO:0032781 [positive regulation of ATPase activity]
GO:0050848 [regulation of calcium-mediated signaling]
Show all
 299 aa
33.3 kDa 		No 0
RGN-201
ENSP00000380365
ENST00000397180
Q15493 [Direct mapping]
Regucalcin
V9HWF8 [Target identity:100%; Query identity:100%]
Epididymis secretory protein Li 41
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001822 [kidney development]
GO:0001889 [liver development]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0004341 [gluconolactonase activity]
GO:0005509 [calcium ion binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006469 [negative regulation of protein kinase activity]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007283 [spermatogenesis]
GO:0007568 [aging]
GO:0008270 [zinc ion binding]
GO:0010867 [positive regulation of triglyceride biosynthetic process]
GO:0010907 [positive regulation of glucose metabolic process]
GO:0010922 [positive regulation of phosphatase activity]
GO:0019853 [L-ascorbic acid biosynthetic process]
GO:0030234 [enzyme regulator activity]
GO:0032515 [negative regulation of phosphoprotein phosphatase activity]
GO:0032781 [positive regulation of ATPase activity]
GO:0034260 [negative regulation of GTPase activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0045019 [negative regulation of nitric oxide biosynthetic process]
GO:0045723 [positive regulation of fatty acid biosynthetic process]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0050848 [regulation of calcium-mediated signaling]
GO:0051344 [negative regulation of cyclic-nucleotide phosphodiesterase activity]
GO:0097421 [liver regeneration]
GO:1901318 [negative regulation of sperm motility]
GO:1901671 [positive regulation of superoxide dismutase activity]
GO:1901896 [positive regulation of calcium-transporting ATPase activity]
GO:1902679 [negative regulation of RNA biosynthetic process]
GO:1903011 [negative regulation of bone development]
GO:1903052 [positive regulation of proteolysis involved in cellular protein catabolic process]
GO:1903611 [negative regulation of calcium-dependent ATPase activity]
GO:1903625 [negative regulation of DNA catabolic process]
GO:1903629 [positive regulation of dUTP diphosphatase activity]
GO:1903634 [negative regulation of leucine-tRNA ligase activity]
GO:2000279 [negative regulation of DNA biosynthetic process]
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 299 aa
33.3 kDa 		No 0
RGN-202
ENSP00000406568
ENST00000457380
Q15493 [Direct mapping]
Regucalcin
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004341 [gluconolactonase activity]
GO:0005509 [calcium ion binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006874 [cellular calcium ion homeostasis]
GO:0008270 [zinc ion binding]
GO:0030234 [enzyme regulator activity]
GO:0032781 [positive regulation of ATPase activity]
GO:0050848 [regulation of calcium-mediated signaling]
Show all
 227 aa
25 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.