Cell atlas - POLN - The Human Protein Atlas

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POLN

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	POLN
Gene description	Polymerase (DNA directed) nu
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA035939 , HPA035940
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm.

Main location

Nucleoplasm (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA035939	RH-30	Nucleoplasm
	HPA035939	U-2 OS	Nucleus
	HPA035940	HEK 293	Nucleoplasm
	HPA035940	RH-30	Nucleoplasm
	HPA035940	U-2 OS	Nucleoplasm

GENE INFORMATION
Gene name	POLN
Synonyms
Description	Polymerase (DNA directed) nu (HGNC Symbol)
Entrez gene summary	This gene encodes a DNA polymerase type-A family member. The encoded protein plays a role in DNA repair and homologous recombination. This gene shares its 5' exons with some transcripts from overlapping GeneID: 79441, which encodes an augmentin-like protein complex subunit. [provided by RefSeq, Dec 2014]
Chromosome	4
Cytoband	p16.3
Chromosome location (bp)	2071918 - 2242121
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000130997 (version 83.38)
Entrez gene	353497
UniProt	Q7Z5Q5 (UniProt - Evidence at protein level)
neXtProt	NX_Q7Z5Q5
Antibodypedia	POLN antibodies

PROTEIN BROWSER

POLN-001	POLN-004	POLN-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
POLN-001 ENSP00000435506 ENST00000511885	Q7Z5Q5 [Direct mapping] DNA polymerase nu Show all	Enzymes ENZYME proteins Transferases THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0000724 [double-strand break repair via homologous recombination] GO:0003677 [DNA binding] GO:0003887 [DNA-directed DNA polymerase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006260 [DNA replication] GO:0006261 [DNA-dependent DNA replication] GO:0006281 [DNA repair] GO:0008409 [5'-3' exonuclease activity] GO:0019985 [translesion synthesis] GO:0030332 [cyclin binding] GO:0036297 [interstrand cross-link repair] GO:0043231 [intracellular membrane-bounded organelle] GO:0090305 [nucleic acid phosphodiester bond hydrolysis] Show all	900 aa 100.3 kDa	No	0
POLN-004 ENSP00000426401 ENST00000511098	H0YA88 [Direct mapping] DNA polymerase nu Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0003887 [DNA-directed DNA polymerase activity] GO:0006260 [DNA replication] GO:0006261 [DNA-dependent DNA replication] GO:0071897 [DNA biosynthetic process] Show all	524 aa 58.4 kDa	No	0
POLN-201 ENSP00000372316 ENST00000382865	Q7Z5Q5 [Direct mapping] DNA polymerase nu Show all	Enzymes ENZYME proteins Transferases THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0000724 [double-strand break repair via homologous recombination] GO:0003677 [DNA binding] GO:0003887 [DNA-directed DNA polymerase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006260 [DNA replication] GO:0006261 [DNA-dependent DNA replication] GO:0006281 [DNA repair] GO:0008409 [5'-3' exonuclease activity] GO:0019985 [translesion synthesis] GO:0030332 [cyclin binding] GO:0036297 [interstrand cross-link repair] GO:0043231 [intracellular membrane-bounded organelle] GO:0090305 [nucleic acid phosphodiester bond hydrolysis] Show all	900 aa 100.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.