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LATS1

GENERAL INFORMATION

Gene name

 LATS1

Gene description

 Large tumor suppressor kinase 1

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA031804
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA031804

GENE INFORMATION

Gene name

 LATS1 (HGNC Symbol)

Synonyms

 WARTS

Description

 Large tumor suppressor kinase 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. Two protein-coding transcripts and one non-protein coding transcript have been found for this gene. [provided by RefSeq, Jul 2012]

Chromosome

 6

Cytoband

 q25.1

Chromosome location (bp)

 149658153 - 149718256

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000131023 (version 83.38)

Entrez gene

 9113

UniProt

 O95835 (UniProt - Evidence at protein level)

neXtProt

 NX_O95835

Antibodypedia

 LATS1 antibodies

PROTEIN BROWSER
LATS1-001
LATS1-003
LATS1-005
LATS1-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LATS1-001
ENSP00000437550
ENST00000543571
O95835 [Direct mapping]
Serine/threonine-protein kinase LATS1
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000287 [magnesium ion binding]
GO:0000819 [sister chromatid segregation]
GO:0000922 [spindle pole]
GO:0001827 [inner cell mass cell fate commitment]
GO:0001828 [inner cell mass cellular morphogenesis]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0007067 [mitotic nuclear division]
GO:0009755 [hormone-mediated signaling pathway]
GO:0019901 [protein kinase binding]
GO:0030216 [keratinocyte differentiation]
GO:0030833 [regulation of actin filament polymerization]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034613 [cellular protein localization]
GO:0035329 [hippo signaling]
GO:0043065 [positive regulation of apoptotic process]
GO:0043254 [regulation of protein complex assembly]
GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0046620 [regulation of organ growth]
GO:0051220 [cytoplasmic sequestering of protein]
GO:0051301 [cell division]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
Show all
 1130 aa
126.9 kDa 		No 0
LATS1-003
ENSP00000444678
ENST00000392273
O95835 [Direct mapping]
Serine/threonine-protein kinase LATS1
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000287 [magnesium ion binding]
GO:0000819 [sister chromatid segregation]
GO:0000922 [spindle pole]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0007067 [mitotic nuclear division]
GO:0009755 [hormone-mediated signaling pathway]
GO:0019901 [protein kinase binding]
GO:0030833 [regulation of actin filament polymerization]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0035329 [hippo signaling]
GO:0043065 [positive regulation of apoptotic process]
GO:0043254 [regulation of protein complex assembly]
GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0046620 [regulation of organ growth]
GO:0051220 [cytoplasmic sequestering of protein]
GO:0051301 [cell division]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
Show all
 690 aa
76.2 kDa 		No 0
LATS1-005
ENSP00000253339
ENST00000253339
O95835 [Direct mapping]
Serine/threonine-protein kinase LATS1
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   AGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000287 [magnesium ion binding]
GO:0000819 [sister chromatid segregation]
GO:0000922 [spindle pole]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005815 [microtubule organizing center]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0007067 [mitotic nuclear division]
GO:0009755 [hormone-mediated signaling pathway]
GO:0019901 [protein kinase binding]
GO:0030833 [regulation of actin filament polymerization]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0035329 [hippo signaling]
GO:0043065 [positive regulation of apoptotic process]
GO:0043254 [regulation of protein complex assembly]
GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0046620 [regulation of organ growth]
GO:0051220 [cytoplasmic sequestering of protein]
GO:0051301 [cell division]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
Show all
 1130 aa
126.9 kDa 		No 0
LATS1-007
ENSP00000441265
ENST00000458696
H0YG09 [Direct mapping]
Serine/threonine-protein kinase LATS1
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0007067 [mitotic nuclear division]
GO:0035329 [hippo signaling]
Show all
 201 aa
21.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.