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EPS8L1

GENERAL INFORMATION

Gene name

 EPS8L1

Gene description

 EPS8-like 1

Protein class

 Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (BEWO, T-47d)
HPA (normal tissue):Tissue enhanced (skin, stomach)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Expression in several tissues, including stomach and placenta.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 2 antibodies.
HPA041851 , HPA043545
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (unfavourable).
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Pancreatic cancer

STAINING SUMMARY
HPA041851
HPA043545

GENE INFORMATION

Gene name

 EPS8L1 (HGNC Symbol)

Synonyms

 DRC3, FLJ20258, MGC23164, MGC4642

Description

 EPS8-like 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that is related to epidermal growth factor receptor pathway substrate 8 (EPS8), a substrate for the epidermal growth factor receptor. The function of this protein is unknown. At least two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.42

Chromosome location (bp)

 55072020 - 55087923

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000131037 (version 83.38)

Entrez gene

 54869

UniProt

 Q8TE68 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8TE68

Antibodypedia

 EPS8L1 antibodies

PROTEIN BROWSER
EPS8L1-001
EPS8L1-002
EPS8L1-004
EPS8L1-006
EPS8L1-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EPS8L1-001
ENSP00000201647
ENST00000201647
Q8TE68 [Direct mapping]
Epidermal growth factor receptor kinase substrate 8-like protein 1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003779 [actin binding]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0007266 [Rho protein signal transduction]
GO:0030676 [Rac guanyl-nucleotide exchange factor activity]
GO:0032587 [ruffle membrane]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0042608 [T cell receptor binding]
GO:0043234 [protein complex]
GO:0043547 [positive regulation of GTPase activity]
GO:0070062 [extracellular exosome]
GO:1900029 [positive regulation of ruffle assembly]
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 723 aa
80.3 kDa 		No 0
EPS8L1-002
ENSP00000466828
ENST00000586329
K7EN83 [Direct mapping]
EPS8-like 1, isoform CRA_d; Epidermal growth factor receptor kinase substrate 8-like protein 1
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 548 aa
61.3 kDa 		Yes 0
EPS8L1-004
ENSP00000437541
ENST00000540810
B4DKV7 [Direct mapping]
Epidermal growth factor receptor kinase substrate 8-like protein 1; cDNA FLJ60287, highly similar to Epidermal growth factor receptor kinase substrate 8-like protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
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 659 aa
73.3 kDa 		No 0
EPS8L1-006
ENSP00000245618
ENST00000245618
Q8TE68 [Direct mapping]
Epidermal growth factor receptor kinase substrate 8-like protein 1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0007266 [Rho protein signal transduction]
GO:0030676 [Rac guanyl-nucleotide exchange factor activity]
GO:0032587 [ruffle membrane]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0042608 [T cell receptor binding]
GO:0043234 [protein complex]
GO:0043547 [positive regulation of GTPase activity]
GO:0070062 [extracellular exosome]
GO:1900029 [positive regulation of ruffle assembly]
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 596 aa
66.5 kDa 		No 0
EPS8L1-007
ENSP00000466245
ENST00000588359
K7ELW3 [Direct mapping]
Epidermal growth factor receptor kinase substrate 8-like protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 409 aa
46.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.