Tissue expression of COX4I2 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	COX4I2
Gene description	Cytochrome c oxidase subunit IV isoform 2 (lung)
Protein class	Disease related genes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (lung, placenta)
GTEx:	Tissue enhanced (lung)
FANTOM5:	Tissue enhanced (placenta)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (lung, placenta)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lung)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (placenta)

GENE INFORMATION
Gene name	COX4I2 (HGNC Symbol)
Synonyms	COX4-2, COX4B, COX4L2, COXIV-2, dJ857M17.2
Description	Cytochrome c oxidase subunit IV isoform 2 (lung) (HGNC Symbol)
Entrez gene summary	Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes isoform 2 of subunit IV. Isoform 1 of subunit IV is encoded by a different gene, however, the two genes show a similar structural organization. Subunit IV is the largest nuclear encoded subunit which plays a pivotal role in COX regulation. [provided by RefSeq, Jul 2008]
Chromosome	20
Cytoband	q11.21
Chromosome location (bp)	31637888 - 31645006
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000131055 (version 83.38)
Entrez gene	84701
UniProt	Q96KJ9 (UniProt - Evidence at protein level)
neXtProt	NX_Q96KJ9
Antibodypedia	COX4I2 antibodies

PROTEIN BROWSER

COX4I2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COX4I2-001 ENSP00000365243 ENST00000376075	Q96KJ9 [Direct mapping] Cytochrome c oxidase subunit 4 isoform 2, mitochondrial H6SG14 [Target identity:100%; Query identity:100%] Cytochrome c oxidase subunit IV isoform 2; Cytochrome c oxidase subunit IV isoform 2 (Lung) Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004129 [cytochrome-c oxidase activity] GO:0005739 [mitochondrion] GO:0005751 [mitochondrial respiratory chain complex IV] GO:0006091 [generation of precursor metabolites and energy] GO:0006123 [mitochondrial electron transport, cytochrome c to oxygen] GO:0009060 [aerobic respiration] GO:0031966 [mitochondrial membrane] GO:0045333 [cellular respiration] GO:0055114 [oxidation-reduction process] GO:1902600 [hydrogen ion transmembrane transport] Show all	171 aa 20 kDa	No	1