Tissue expression of DEFB118 - Summary - The Human Protein Atlas

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DEFB118

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	DEFB118
Gene description	Defensin, beta 118
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (epididymis)
GTEx:	Not detected
FANTOM5:	Tissue enriched (epididymis)

Protein evidence

Evidence at transcript level

Protein expression

Cytoplasmic staining in several tissues, most abundant in epididymis.

DATA RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Approved based on 1 antibody. HPA042634
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (epididymis)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Not detected
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (epididymis)

GENE INFORMATION
Gene name	DEFB118 (HGNC Symbol)
Synonyms	C20orf63, DEFB-18, dJ1018D12.3, ESC42
Description	Defensin, beta 118 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the beta subfamily of defensins. Beta-defensins are antimicrobial peptides that protect tissues and organs from infection by a variety of microorganisms. Expression of this gene is regulated by androgen, and the encoded protein binds to sperm and exhibits antibacterial activity against E. coli. This gene is found in a cluster with other beta-defensin genes on the long arm of chromosome 20. [provided by RefSeq, Nov 2014]
Chromosome	20
Cytoband	q11.21
Chromosome location (bp)	31368618 - 31373923
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000131068 (version 83.38)
Entrez gene	117285
UniProt	Q96PH6 (UniProt - Evidence at transcript level)
neXtProt	NX_Q96PH6
Antibodypedia	DEFB118 antibodies

PROTEIN BROWSER

DEFB118-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DEFB118-001 ENSP00000253381 ENST00000253381	Q96PH6 [Direct mapping] Beta-defensin 118 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005576 [extracellular region] GO:0007160 [cell-matrix adhesion] GO:0007283 [spermatogenesis] GO:0009986 [cell surface] GO:0042742 [defense response to bacterium] GO:0045087 [innate immune response] Show all	123 aa 13.6 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.