Expression of ACSS2 in cancer - Summary

GENERAL INFORMATION
Gene name	ACSS2
Gene description	Acyl-CoA synthetase short-chain family member 2
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in several tissues, most abundant in gastrointestinal tract, heart and skeletal muscle.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA004141
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA004141

GENE INFORMATION
Gene name	ACSS2 (HGNC Symbol)
Synonyms	ACAS2, AceCS, ACS, ACSA, dJ1161H23.1
Description	Acyl-CoA synthetase short-chain family member 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]
Chromosome	20
Cytoband	q11.22
Chromosome location (bp)	34872146 - 34927962
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000131069 (version 83.38)
Entrez gene	55902
UniProt	Q9NR19 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NR19
Antibodypedia	ACSS2 antibodies

PROTEIN BROWSER

ACSS2-001	ACSS2-006	ACSS2-012	ACSS2-016	ACSS2-019	ACSS2-020

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACSS2-001 ENSP00000353804 ENST00000360596	Q9NR19 [Direct mapping] Acetyl-coenzyme A synthetase, cytoplasmic Show all	Enzymes ENZYME proteins Ligase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0003987 [acetate-CoA ligase activity] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006069 [ethanol oxidation] GO:0006805 [xenobiotic metabolic process] GO:0008152 [metabolic process] GO:0008610 [lipid biosynthetic process] GO:0016208 [AMP binding] GO:0019427 [acetyl-CoA biosynthetic process from acetate] GO:0043231 [intracellular membrane-bounded organelle] GO:0044281 [small molecule metabolic process] Show all	701 aa 78.6 kDa	No	1
ACSS2-006 ENSP00000253382 ENST00000253382	Q9NR19 [Direct mapping] Acetyl-coenzyme A synthetase, cytoplasmic Show all	Enzymes ENZYME proteins Ligase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0003987 [acetate-CoA ligase activity] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006069 [ethanol oxidation] GO:0006085 [acetyl-CoA biosynthetic process] GO:0006805 [xenobiotic metabolic process] GO:0008152 [metabolic process] GO:0008610 [lipid biosynthetic process] GO:0016208 [AMP binding] GO:0019413 [acetate biosynthetic process] GO:0019427 [acetyl-CoA biosynthetic process from acetate] GO:0019542 [propionate biosynthetic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0044281 [small molecule metabolic process] Show all	714 aa 80.1 kDa	No	1
ACSS2-012 ENSP00000417783 ENST00000488172	C9J7L5 [Direct mapping] Acetyl-coenzyme A synthetase, cytoplasmic Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	163 aa 18.7 kDa	No	1
ACSS2-016 ENSP00000419167 ENST00000484354	C9JXD9 [Direct mapping] Acetyl-coenzyme A synthetase, cytoplasmic Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		148 aa 17 kDa	No	0
ACSS2-019 ENSP00000418812 ENST00000493805	C9IYL0 [Direct mapping] Acetyl-coenzyme A synthetase, cytoplasmic Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	182 aa 20.8 kDa	No	0
ACSS2-020 ENSP00000419925 ENST00000473172	C9JY31 [Direct mapping] Acetyl-coenzyme A synthetase, cytoplasmic Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	203 aa 23.1 kDa	No	1