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EDA2R

GENERAL INFORMATION

Gene name

 EDA2R

Gene description

 Ectodysplasin A2 receptor

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (BJ hTERT+, LHCN-M2)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 EDA2R (HGNC Symbol)

Synonyms

 EDA-A2R, EDAA2R, TNFRSF27, XEDAR

Description

 Ectodysplasin A2 receptor (HGNC Symbol)

Entrez gene summary

 EDA-A1 and EDA-A2 are two isoforms of ectodysplasin that are encoded by the anhidrotic ectodermal dysplasia (EDA) gene. Mutations in EDA give rise to a clinical syndrome characterized by loss of hair, sweat glands, and teeth. The protein encoded by this gene specifically binds to EDA-A2 isoform. This protein is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily, and contains 3 cysteine-rich repeats and a single transmembrane domain but lacks an N-terminal signal peptide. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, May 2011]

Chromosome

 X

Cytoband

 q12

Chromosome location (bp)

 66595637 - 66639298

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000131080 (version 83.38)

Entrez gene

 60401

UniProt

 Q9HAV5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9HAV5

Antibodypedia

 EDA2R antibodies

PROTEIN BROWSER
EDA2R-001
EDA2R-002
EDA2R-201
EDA2R-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EDA2R-001
ENSP00000363851
ENST00000374719
Q9HAV5 [Direct mapping]
Tumor necrosis factor receptor superfamily member 27
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0004872 [receptor activity]
GO:0005031 [tumor necrosis factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007275 [multicellular organismal development]
GO:0008544 [epidermis development]
GO:0010668 [ectodermal cell differentiation]
GO:0016021 [integral component of membrane]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0046330 [positive regulation of JNK cascade]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
Show all
 297 aa
32.8 kDa 		No 1
EDA2R-002
ENSP00000253392
ENST00000253392
Q9HAV5 [Direct mapping]
Tumor necrosis factor receptor superfamily member 27
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0004872 [receptor activity]
GO:0005031 [tumor necrosis factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007275 [multicellular organismal development]
GO:0008544 [epidermis development]
GO:0010668 [ectodermal cell differentiation]
GO:0016021 [integral component of membrane]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0046330 [positive regulation of JNK cascade]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
Show all
 318 aa
35.1 kDa 		No 1
EDA2R-201
ENSP00000379365
ENST00000396050
Q9HAV5 [Direct mapping]
Tumor necrosis factor receptor superfamily member 27
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0004872 [receptor activity]
GO:0005031 [tumor necrosis factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007275 [multicellular organismal development]
GO:0008544 [epidermis development]
GO:0010668 [ectodermal cell differentiation]
GO:0016021 [integral component of membrane]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0046330 [positive regulation of JNK cascade]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator]
Show all
 318 aa
35.1 kDa 		No 1
EDA2R-202
ENSP00000415242
ENST00000451436
Q9HAV5 [Direct mapping]
Tumor necrosis factor receptor superfamily member 27
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0004872 [receptor activity]
GO:0005031 [tumor necrosis factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007275 [multicellular organismal development]
GO:0008544 [epidermis development]
GO:0010668 [ectodermal cell differentiation]
GO:0016021 [integral component of membrane]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0046330 [positive regulation of JNK cascade]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
Show all
 297 aa
32.8 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.