Cell atlas - GFAP - The Human Protein Atlas

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GFAP

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Intermediate filaments

Human cell
	Intermediate Filaments

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GENERAL INFORMATION
Gene name	GFAP
Gene description	Glial fibrillary acidic protein
Protein class	Candidate cardiovascular disease genes Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	13
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the intermediate filaments.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Intermediate filaments (supported)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA056030
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the intermediate filaments.

Main location

Intermediate filaments (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA056030	HEK 293	Intermediate filaments	Intensity
	HPA056030	U-2 OS	Intermediate filaments	Intensity

GENE INFORMATION
Gene name	GFAP (HGNC Symbol)
Synonyms	FLJ45472
Description	Glial fibrillary acidic protein (HGNC Symbol)
Entrez gene summary	This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
Chromosome	17
Cytoband	q21.31
Chromosome location (bp)	44905008 - 44916937
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000131095 (version 83.38)
Entrez gene	2670
UniProt	P14136 (UniProt - Evidence at protein level)
neXtProt	NX_P14136
Antibodypedia	GFAP antibodies

PROTEIN BROWSER

GFAP-001	GFAP-002	GFAP-005	GFAP-006	GFAP-008	GFAP-009	GFAP-011	GFAP-015	GFAP-018	GFAP-019	GFAP-021	GFAP-023	GFAP-024

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GFAP-001 ENSP00000253408 ENST00000253408	P14136 [Direct mapping] Glial fibrillary acidic protein Show all	Predicted intracellular proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005882 [intermediate filament] Show all	432 aa 49.9 kDa	No	0
GFAP-002 ENSP00000403962 ENST00000435360	P14136 [Direct mapping] Glial fibrillary acidic protein Show all	Predicted intracellular proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005882 [intermediate filament] Show all	431 aa 49.5 kDa	No	0
GFAP-005 ENSP00000465320 ENST00000592320	K7EJU1 [Direct mapping] Glial fibrillary acidic protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005882 [intermediate filament] Show all	248 aa 28.5 kDa	No	0
GFAP-006 ENSP00000466163 ENST00000588037	K7ELP4 [Direct mapping] Glial fibrillary acidic protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005882 [intermediate filament] Show all	189 aa 21.3 kDa	No	0
GFAP-008 ENSP00000466598 ENST00000588735	K7EMP8 [Direct mapping] Glial fibrillary acidic protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		58 aa 6.6 kDa	No	0
GFAP-009 ENSP00000464795 ENST00000586127	K7EIL2 [Direct mapping] Glial fibrillary acidic protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		12 aa 1.4 kDa	No	0
GFAP-011 ENSP00000465624 ENST00000587997	K7EKH6 [Direct mapping] Glial fibrillary acidic protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005882 [intermediate filament] Show all	191 aa 22.4 kDa	No	0
GFAP-015 ENSP00000467530 ENST00000591880	K7EPT8 [Direct mapping] Glial fibrillary acidic protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005882 [intermediate filament] Show all	101 aa 11.4 kDa	No	0
GFAP-018 ENSP00000465629 ENST00000588316	K7EKH9 [Direct mapping] Glial fibrillary acidic protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005882 [intermediate filament] Show all	261 aa 29.8 kDa	No	0
GFAP-019 ENSP00000467397 ENST00000586125	K7EPI4 [Direct mapping] Glial fibrillary acidic protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		64 aa 7.1 kDa	No	0
GFAP-021 ENSP00000465565 ENST00000588957	K7EKD1 [Direct mapping] Glial fibrillary acidic protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005882 [intermediate filament] Show all	57 aa 6.6 kDa	No	0
GFAP-023 ENSP00000467106 ENST00000593179	A0A0G2JLI8 [Direct mapping] Glial fibrillary acidic protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		9 aa 1.1 kDa	No	0
GFAP-024 ENSP00000468500 ENST00000586793	P14136 [Direct mapping] Glial fibrillary acidic protein Show all	Predicted intracellular proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005178 [integrin binding] GO:0005198 [structural molecule activity] GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005882 [intermediate filament] GO:0009611 [response to wounding] GO:0010625 [positive regulation of Schwann cell proliferation] GO:0010977 [negative regulation of neuron projection development] GO:0014002 [astrocyte development] GO:0016020 [membrane] GO:0019900 [kinase binding] GO:0030198 [extracellular matrix organization] GO:0031102 [neuron projection regeneration] GO:0042995 [cell projection] GO:0043209 [myelin sheath] GO:0044297 [cell body] GO:0045103 [intermediate filament-based process] GO:0045109 [intermediate filament organization] GO:0051580 [regulation of neurotransmitter uptake] GO:0060020 [Bergmann glial cell differentiation] GO:0060252 [positive regulation of glial cell proliferation] GO:0060291 [long-term synaptic potentiation] GO:0097386 [glial cell projection] GO:0097449 [astrocyte projection] GO:0097450 [astrocyte end-foot] Show all	438 aa 50.3 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.