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PYY

GENERAL INFORMATION

Gene name

 PYY

Gene description

 Peptide YY

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (endometrial cancer, ovarian cancer, testis cancer)
HPA (cell line):Cell line enhanced (HMC-1)
HPA (normal tissue):Group enriched (colon, rectum, small intestine)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective expression of enteroendocrine cells in the gastrointestinal tract.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Supported based on 2 antibodies.
HPA010973 , CAB016734
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (endometrial cancer, ovarian cancer, testis cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Carcinoid

STAINING SUMMARY
HPA010973
CAB016734

GENE INFORMATION

Gene name

 PYY (HGNC Symbol)

Synonyms

 PYY1

Description

 Peptide YY (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is proteolytically processed to release a peptide that inhibits pancreatic secretion and mobility in the gut. Rare variations in this gene could increase susceptibility to obesity. [provided by RefSeq, Jul 2010]

Chromosome

 17

Cytoband

 q21.31

Chromosome location (bp)

 43952738 - 44004469

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000131096 (version 83.38)

Entrez gene

 5697

UniProt

 P10082 (UniProt - Evidence at protein level)

neXtProt

 NX_P10082

Antibodypedia

 PYY antibodies

PROTEIN BROWSER
PYY-001
PYY-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PYY-001
ENSP00000353198
ENST00000360085
P10082 [Direct mapping]
Peptide YY Peptide YY(3-36)
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   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001664 [G-protein coupled receptor binding]
GO:0005179 [hormone activity]
GO:0005184 [neuropeptide hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006928 [movement of cell or subcellular component]
GO:0007010 [cytoskeleton organization]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007218 [neuropeptide signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007586 [digestion]
GO:0007631 [feeding behavior]
GO:0008283 [cell proliferation]
GO:0032098 [regulation of appetite]
GO:0042755 [eating behavior]
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 97 aa
11.1 kDa 		Yes 0
PYY-002
ENSP00000467310
ENST00000592796
P10082 [Direct mapping]
Peptide YY Peptide YY(3-36)
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0001664 [G-protein coupled receptor binding]
GO:0005179 [hormone activity]
GO:0005184 [neuropeptide hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006928 [movement of cell or subcellular component]
GO:0007010 [cytoskeleton organization]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007218 [neuropeptide signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0007586 [digestion]
GO:0007631 [feeding behavior]
GO:0008283 [cell proliferation]
GO:0032098 [regulation of appetite]
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 90 aa
10.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.