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SLC34A1

GENERAL INFORMATION

Gene name

 SLC34A1

Gene description

 Solute carrier family 34 (type II sodium/phosphate cotransporter), member 1

Protein class

 Disease related genes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (renal cancer)
HPA (cell line):Group enriched (HEL, U-937)
HPA (normal tissue):Tissue enriched (kidney)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in kidney.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA051255
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (renal cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA051255

GENE INFORMATION

Gene name

 SLC34A1 (HGNC Symbol)

Synonyms

 NAPI-3, NPT2, NPTIIa, SLC11, SLC17A2

Description

 Solute carrier family 34 (type II sodium/phosphate cotransporter), member 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the type II sodium-phosphate cotransporter family. Mutations in this gene are associated with hypophosphatemia nephrolithiasis/osteoporosis 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]

Chromosome

 5

Cytoband

 q35.3

Chromosome location (bp)

 177379235 - 177398848

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000131183 (version 83.38)

Entrez gene

 6569

UniProt

 Q06495 (UniProt - Evidence at protein level)

neXtProt

 NX_Q06495

Antibodypedia

 SLC34A1 antibodies

PROTEIN BROWSER
SLC34A1-001
SLC34A1-002
SLC34A1-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC34A1-001
ENSP00000321424
ENST00000324417
Q06495 [Direct mapping]
Sodium-dependent phosphate transport protein 2A
A0A024R7R9 [Target identity:100%; Query identity:100%]
Solute carrier family 34 (Sodium phosphate), member 1, isoform CRA_b
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   9TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
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GO:0001503 [ossification]
GO:0001822 [kidney development]
GO:0005515 [protein binding]
GO:0005768 [endosome]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006814 [sodium ion transport]
GO:0006817 [phosphate ion transport]
GO:0007584 [response to nutrient]
GO:0009100 [glycoprotein metabolic process]
GO:0009986 [cell surface]
GO:0010288 [response to lead ion]
GO:0015293 [symporter activity]
GO:0015321 [sodium-dependent phosphate transmembrane transporter activity]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0030165 [PDZ domain binding]
GO:0031226 [intrinsic component of plasma membrane]
GO:0031526 [brush border membrane]
GO:0031988 [membrane-bounded vesicle]
GO:0032026 [response to magnesium ion]
GO:0032355 [response to estradiol]
GO:0032403 [protein complex binding]
GO:0033189 [response to vitamin A]
GO:0035864 [response to potassium ion]
GO:0042431 [indole metabolic process]
GO:0042493 [response to drug]
GO:0042803 [protein homodimerization activity]
GO:0043434 [response to peptide hormone]
GO:0044267 [cellular protein metabolic process]
GO:0044341 [sodium-dependent phosphate transport]
GO:0045121 [membrane raft]
GO:0045838 [positive regulation of membrane potential]
GO:0046686 [response to cadmium ion]
GO:0046689 [response to mercury ion]
GO:0046849 [bone remodeling]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051260 [protein homooligomerization]
GO:0055062 [phosphate ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0060416 [response to growth hormone]
GO:0071107 [response to parathyroid hormone]
GO:0071248 [cellular response to metal ion]
GO:0071374 [cellular response to parathyroid hormone stimulus]
GO:0072350 [tricarboxylic acid metabolic process]
GO:0072734 [cellular response to staurosporine]
GO:0097066 [response to thyroid hormone]
GO:0097187 [dentinogenesis]
GO:1901128 [gentamycin metabolic process]
GO:1901652 [response to peptide]
GO:1901684 [arsenate ion transmembrane transport]
GO:2000120 [positive regulation of sodium-dependent phosphate transport]
GO:2000187 [positive regulation of phosphate transmembrane transport]
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 639 aa
68.9 kDa 		No 9
SLC34A1-002
ENSP00000423022
ENST00000512593
Q06495 [Direct mapping]
Sodium-dependent phosphate transport protein 2A
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006814 [sodium ion transport]
GO:0006817 [phosphate ion transport]
GO:0010288 [response to lead ion]
GO:0015293 [symporter activity]
GO:0015321 [sodium-dependent phosphate transmembrane transporter activity]
GO:0016020 [membrane]
GO:0031526 [brush border membrane]
GO:0044267 [cellular protein metabolic process]
GO:0044341 [sodium-dependent phosphate transport]
GO:0046686 [response to cadmium ion]
GO:0046689 [response to mercury ion]
GO:0055062 [phosphate ion homeostasis]
GO:0055085 [transmembrane transport]
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 340 aa
36.6 kDa 		No 3
SLC34A1-005
ENSP00000423733
ENST00000504577
D6RCE5 [Direct mapping]
Sodium-dependent phosphate transport protein 2A
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Predicted intracellular proteins
Show all
GO:0005886 [plasma membrane]
GO:0015321 [sodium-dependent phosphate transmembrane transporter activity]
GO:0044341 [sodium-dependent phosphate transport]
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 109 aa
11.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.