The malignant cells were in most cases negative or occasionally showed weak cytoplasmic staining. Hepatocellular cancers and several cases of testicular cancers showed distinct cytoplasmic positivity.
ADGRE3 (HGNC Symbol)
Adhesion G protein-coupled receptor E3 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 on chromosome 19. This protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]