Expression of HACL1 in cancer - Summary - The Human Protein Atlas

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HACL1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	HACL1
Gene description	2-hydroxyacyl-CoA lyase 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA035496 , HPA035497
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA035496	HPA035497

GENE INFORMATION
Gene name	HACL1 (HGNC Symbol)
Synonyms	2-HPCL, HPCL, PHYH2
Description	2-hydroxyacyl-CoA lyase 1 (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	p25.1
Chromosome location (bp)	15560704 - 15601852
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000131373 (version 83.38)
Entrez gene	26061
UniProt	Q9UJ83 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UJ83
Antibodypedia	HACL1 antibodies

PROTEIN BROWSER

HACL1-001	HACL1-002	HACL1-003	HACL1-005	HACL1-007	HACL1-008	HACL1-009	HACL1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HACL1-001 ENSP00000323811 ENST00000321169	Q9UJ83 [Direct mapping] 2-hydroxyacyl-CoA lyase 1 Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0001561 [fatty acid alpha-oxidation] GO:0003824 [catalytic activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005777 [peroxisome] GO:0005782 [peroxisomal matrix] GO:0006629 [lipid metabolic process] GO:0016829 [lyase activity] GO:0016830 [carbon-carbon lyase activity] GO:0030976 [thiamine pyrophosphate binding] GO:0042802 [identical protein binding] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0048037 [cofactor binding] GO:0051259 [protein oligomerization] Show all	578 aa 63.7 kDa	No	0
HACL1-002 ENSP00000403656 ENST00000451445	Q9UJ83 [Direct mapping] 2-hydroxyacyl-CoA lyase 1 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0001561 [fatty acid alpha-oxidation] GO:0003824 [catalytic activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005777 [peroxisome] GO:0005782 [peroxisomal matrix] GO:0016830 [carbon-carbon lyase activity] GO:0030976 [thiamine pyrophosphate binding] GO:0042802 [identical protein binding] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0048037 [cofactor binding] GO:0051259 [protein oligomerization] Show all	496 aa 54.7 kDa	No	0
HACL1-003 ENSP00000395278 ENST00000435217	B3KPX4 [Direct mapping] 2-hydroxyacyl-CoA lyase 1; Phytanoyl-CoA 2-hydroxylase 2, isoform CRA_c; cDNA FLJ32415 fis, clone SKMUS2000724, highly similar to 2-hydroxyphytanoyl-CoA lyase (EC 4.1.-.-) Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] GO:0016829 [lyase activity] GO:0030976 [thiamine pyrophosphate binding] Show all	337 aa 37.6 kDa	No	0
HACL1-005 ENSP00000390699 ENST00000456194	Q9UJ83 [Direct mapping] 2-hydroxyacyl-CoA lyase 1 Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0001561 [fatty acid alpha-oxidation] GO:0003824 [catalytic activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005777 [peroxisome] GO:0005782 [peroxisomal matrix] GO:0016830 [carbon-carbon lyase activity] GO:0030976 [thiamine pyrophosphate binding] GO:0042802 [identical protein binding] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0048037 [cofactor binding] GO:0051259 [protein oligomerization] Show all	551 aa 61.1 kDa	No	0
HACL1-007 ENSP00000404883 ENST00000457447	Q9UJ83 [Direct mapping] 2-hydroxyacyl-CoA lyase 1 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0001561 [fatty acid alpha-oxidation] GO:0003824 [catalytic activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005777 [peroxisome] GO:0005782 [peroxisomal matrix] GO:0016830 [carbon-carbon lyase activity] GO:0030976 [thiamine pyrophosphate binding] GO:0042802 [identical protein binding] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0048037 [cofactor binding] GO:0051259 [protein oligomerization] Show all	518 aa 56.7 kDa	No	0
HACL1-008 ENSP00000391393 ENST00000421993	C9J306 [Direct mapping] 2-hydroxyacyl-CoA lyase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0030976 [thiamine pyrophosphate binding] Show all	244 aa 26.4 kDa	No	0
HACL1-009 ENSP00000395352 ENST00000414979	C9JJM7 [Direct mapping] 2-hydroxyacyl-CoA lyase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0030976 [thiamine pyrophosphate binding] Show all	157 aa 17.1 kDa	No	0
HACL1-201 ENSP00000486684 ENST00000628377	Q7Z773 [Direct mapping] 2-hydroxyacyl-CoA lyase 1; HACL1 protein Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0030976 [thiamine pyrophosphate binding] Show all	119 aa 12.5 kDa	No	0

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The Human Protein Atlas

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