Expression of SLC6A6 in cancer - Summary

GENERAL INFORMATION
Gene name	SLC6A6
Gene description	Solute carrier family 6 (neurotransmitter transporter), member 6
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous expression in glandular cells, including renal tubules and trophoblastic cells in placenta.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA015028 , HPA016488
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PROGNOSTIC SUMMARY
Prognostic marker in glioma (unfavourable), endometrial cancer (favourable) and liver cancer (unfavourable).
Glioma p<0.001 Endometrial cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA015028	HPA016488

GENE INFORMATION
Gene name	SLC6A6 (HGNC Symbol)
Synonyms	TAUT
Description	Solute carrier family 6 (neurotransmitter transporter), member 6 (HGNC Symbol)
Entrez gene summary	This gene encodes a multi-pass membrane protein that is a member of a family of sodium and chloride-ion dependent transporters. The encoded protein transports taurine and beta-alanine. There is a pseudogene for this gene on chromosome 21. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Chromosome	3
Cytoband	p25.1
Chromosome location (bp)	14402576 - 14489349
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000131389 (version 83.38)
Entrez gene	6533
UniProt	P31641 (UniProt - Evidence at protein level)
neXtProt	NX_P31641
Antibodypedia	SLC6A6 antibodies

PROTEIN BROWSER

SLC6A6-001	SLC6A6-004	SLC6A6-009	SLC6A6-011	SLC6A6-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC6A6-001 ENSP00000481625 ENST00000613060	A0A087WY96 [Direct mapping] Transporter Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005328 [neurotransmitter:sodium symporter activity] GO:0005368 [taurine transmembrane transporter activity] GO:0005369 [taurine:sodium symporter activity] GO:0005887 [integral component of plasma membrane] GO:0006836 [neurotransmitter transport] GO:0015734 [taurine transport] GO:0016021 [integral component of membrane] GO:0030977 [taurine binding] GO:0055085 [transmembrane transport] GO:1903825 [organic acid transmembrane transport] Show all	721 aa 81.3 kDa	No	>9
SLC6A6-004 ENSP00000482560 ENST00000621751	P31641 [Direct mapping] Sodium- and chloride-dependent taurine transporter Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003333 [amino acid transmembrane transport] GO:0005328 [neurotransmitter:sodium symporter activity] GO:0005369 [taurine:sodium symporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006520 [cellular amino acid metabolic process] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006836 [neurotransmitter transport] GO:0006865 [amino acid transport] GO:0015734 [taurine transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	200 aa 22.7 kDa	No	3
SLC6A6-009 ENSP00000402059 ENST00000452775	C9JPV1 [Direct mapping] Transporter Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005328 [neurotransmitter:sodium symporter activity] GO:0006836 [neurotransmitter transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	109 aa 12.1 kDa	No	2
SLC6A6-011 ENSP00000399522 ENST00000452151	H7C1B9 [Direct mapping] Sodium- and chloride-dependent taurine transporter Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005328 [neurotransmitter:sodium symporter activity] GO:0006836 [neurotransmitter transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	95 aa 10.8 kDa	Yes	1
SLC6A6-201 ENSP00000480890 ENST00000622186	P31641 [Direct mapping] Sodium- and chloride-dependent taurine transporter Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003333 [amino acid transmembrane transport] GO:0005328 [neurotransmitter:sodium symporter activity] GO:0005369 [taurine:sodium symporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006520 [cellular amino acid metabolic process] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006836 [neurotransmitter transport] GO:0006865 [amino acid transport] GO:0015734 [taurine transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	620 aa 69.8 kDa	No	>9