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KCNC3

GENERAL INFORMATION

Gene name

 KCNC3

Gene description

 Potassium channel, voltage gated Shaw related subfamily C, member 3

Protein class

 Disease related genes
FDA approved drug targets
Predicted intracellular proteins
Predicted membrane proteins
Transporters
Voltage-gated ion channels

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (HMC-1, SK-BR-3, T-47d, U-2 OS)
HPA (normal tissue):Tissue enhanced (parathyroid gland)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and membrane expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA018041
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
HPA018041

GENE INFORMATION

Gene name

 KCNC3 (HGNC Symbol)

Synonyms

 Kv3.3, SCA13

Description

 Potassium channel, voltage gated Shaw related subfamily C, member 3 (HGNC Symbol)

Entrez gene summary

 The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Alternate splicing results in several transcript variants. [provided by RefSeq, Mar 2014]

Chromosome

 19

Cytoband

 q13.33

Chromosome location (bp)

 50311937 - 50333515

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000131398 (version 83.38)

Entrez gene

 3748

UniProt

 Q14003 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14003

Antibodypedia

 KCNC3 antibodies

PROTEIN BROWSER
KCNC3-002
KCNC3-004
KCNC3-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KCNC3-002
ENSP00000366158
ENST00000376959
E7ETH1 [Direct mapping]
Potassium voltage-gated channel subfamily C member 3
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
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GO:0005216 [ion channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005515 [protein binding]
GO:0006811 [ion transport]
GO:0008076 [voltage-gated potassium channel complex]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0034765 [regulation of ion transmembrane transport]
GO:0051260 [protein homooligomerization]
GO:0055085 [transmembrane transport]
GO:0071805 [potassium ion transmembrane transport]
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 728 aa
77.5 kDa 		No 6
KCNC3-004
ENSP00000432438
ENST00000474951
E9PQY4 [Direct mapping]
Potassium voltage-gated channel subfamily C member 3
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Predicted intracellular proteins
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GO:0005251 [delayed rectifier potassium channel activity]
GO:0016021 [integral component of membrane]
GO:0071805 [potassium ion transmembrane transport]
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 44 aa
4.8 kDa 		No 0
KCNC3-005
ENSP00000434241
ENST00000477616
Q14003 [Direct mapping]
Potassium voltage-gated channel subfamily C member 3
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Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0005216 [ion channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006811 [ion transport]
GO:0007268 [synaptic transmission]
GO:0008076 [voltage-gated potassium channel complex]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030673 [axolemma]
GO:0031594 [neuromuscular junction]
GO:0032590 [dendrite membrane]
GO:0032809 [neuronal cell body membrane]
GO:0034765 [regulation of ion transmembrane transport]
GO:0043679 [axon terminus]
GO:0046928 [regulation of neurotransmitter secretion]
GO:0051260 [protein homooligomerization]
GO:0051262 [protein tetramerization]
GO:0055085 [transmembrane transport]
GO:0071805 [potassium ion transmembrane transport]
Show all
 757 aa
80.6 kDa 		No 6

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.