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NR1H2

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GENERAL INFORMATION

Gene name

 NR1H2

Gene description

 Nuclear receptor subfamily 1, group H, member 2

Protein class

 Cancer-related genes
Nuclear receptors
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA070212
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoplasm.

Main location

 Nucleoplasm (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA070212 A549 Nucleoplasm
HPA070212 PC-3 Nucleoplasm
HPA070212 U-2 OS Nucleoplasm

GENE INFORMATION

Gene name

 NR1H2 (HGNC Symbol)

Synonyms

 LXR-b, NER, NER-I, RIP15, UNR

Description

 Nuclear receptor subfamily 1, group H, member 2 (HGNC Symbol)

Entrez gene summary

 The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM, Jan 2010]

Chromosome

 19

Cytoband

 q13.33

Chromosome location (bp)

 50329653 - 50382982

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000131408 (version 83.38)

Entrez gene

 7376

UniProt

 P55055 (UniProt - Evidence at protein level)

neXtProt

 NX_P55055

Antibodypedia

 NR1H2 antibodies

PROTEIN BROWSER
NR1H2-001
NR1H2-002
NR1H2-003
NR1H2-005
NR1H2-006
NR1H2-008
NR1H2-009
NR1H2-011
NR1H2-014

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NR1H2-001
ENSP00000253727
ENST00000253727
P55055 [Direct mapping]
Oxysterols receptor LXR-beta
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001133 [RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010867 [positive regulation of triglyceride biosynthetic process]
GO:0010875 [positive regulation of cholesterol efflux]
GO:0010884 [positive regulation of lipid storage]
GO:0010887 [negative regulation of cholesterol storage]
GO:0032270 [positive regulation of cellular protein metabolic process]
GO:0032369 [negative regulation of lipid transport]
GO:0032376 [positive regulation of cholesterol transport]
GO:0034191 [apolipoprotein A-I receptor binding]
GO:0042632 [cholesterol homeostasis]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0044255 [cellular lipid metabolic process]
GO:0045723 [positive regulation of fatty acid biosynthetic process]
GO:0045861 [negative regulation of proteolysis]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046965 [retinoid X receptor binding]
GO:0048384 [retinoic acid receptor signaling pathway]
GO:0048550 [negative regulation of pinocytosis]
GO:0051006 [positive regulation of lipoprotein lipase activity]
GO:0051117 [ATPase binding]
GO:0055088 [lipid homeostasis]
GO:0060336 [negative regulation of interferon-gamma-mediated signaling pathway]
GO:0090108 [positive regulation of high-density lipoprotein particle assembly]
GO:0090187 [positive regulation of pancreatic juice secretion]
GO:0090340 [positive regulation of secretion of lysosomal enzymes]
GO:2000188 [regulation of cholesterol homeostasis]
Show all
 460 aa
51 kDa 		No 0
NR1H2-002
ENSP00000471194
ENST00000593926
P55055 [Direct mapping]
Oxysterols receptor LXR-beta
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010867 [positive regulation of triglyceride biosynthetic process]
GO:0010875 [positive regulation of cholesterol efflux]
GO:0010887 [negative regulation of cholesterol storage]
GO:0032270 [positive regulation of cellular protein metabolic process]
GO:0032369 [negative regulation of lipid transport]
GO:0032376 [positive regulation of cholesterol transport]
GO:0034191 [apolipoprotein A-I receptor binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045723 [positive regulation of fatty acid biosynthetic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048550 [negative regulation of pinocytosis]
GO:0051006 [positive regulation of lipoprotein lipase activity]
GO:0051117 [ATPase binding]
GO:0060336 [negative regulation of interferon-gamma-mediated signaling pathway]
GO:2000188 [regulation of cholesterol homeostasis]
Show all
 460 aa
51 kDa 		No 0
NR1H2-003
ENSP00000396151
ENST00000411902
P55055 [Direct mapping]
Oxysterols receptor LXR-beta
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0010745 [negative regulation of macrophage derived foam cell differentiation]
GO:0010867 [positive regulation of triglyceride biosynthetic process]
GO:0010875 [positive regulation of cholesterol efflux]
GO:0010887 [negative regulation of cholesterol storage]
GO:0032270 [positive regulation of cellular protein metabolic process]
GO:0032369 [negative regulation of lipid transport]
GO:0032376 [positive regulation of cholesterol transport]
GO:0034191 [apolipoprotein A-I receptor binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0045723 [positive regulation of fatty acid biosynthetic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048550 [negative regulation of pinocytosis]
GO:0051006 [positive regulation of lipoprotein lipase activity]
GO:0051117 [ATPase binding]
GO:0060336 [negative regulation of interferon-gamma-mediated signaling pathway]
GO:2000188 [regulation of cholesterol homeostasis]
Show all
 363 aa
39.9 kDa 		No 0
NR1H2-005
ENSP00000472526
ENST00000599105
M0R2F9 [Direct mapping]
Oxysterols receptor LXR-beta
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
Show all
 416 aa
46 kDa 		No 0
NR1H2-006
ENSP00000470518
ENST00000597790
M0QZF5 [Direct mapping]
Oxysterols receptor LXR-beta
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0043565 [sequence-specific DNA binding]
Show all
 115 aa
12.1 kDa 		No 0
NR1H2-008
ENSP00000472138
ENST00000597130
M0R1V8 [Direct mapping]
Oxysterols receptor LXR-beta
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
Show all
 210 aa
22.3 kDa 		No 0
NR1H2-009
ENSP00000469778
ENST00000597157
M0QYE6 [Direct mapping]
Oxysterols receptor LXR-beta
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
Show all
 228 aa
24.1 kDa 		No 0
NR1H2-011
ENSP00000473099
ENST00000600355
M0R3A7 [Direct mapping]
Oxysterols receptor LXR-beta
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
 41 aa
4 kDa 		No 0
NR1H2-014
ENSP00000471294
ENST00000598168
M0R0K3 [Direct mapping]
Oxysterols receptor LXR-beta
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
Show all
 430 aa
47.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.