Expression of GFPT2 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

GFPT2

TISSUE

premium

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GFPT2
Gene description	Glutamine-fructose-6-phosphate transaminase 2
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (ASC TERT1, U-87 MG)
HPA (normal tissue):	Tissue enhanced (adipose tissue)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA056892 , HPA059910
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), lung cancer (unfavourable), thyroid cancer (unfavourable) and cervical cancer (unfavourable).
Renal cancer p<0.001 Lung cancer p<0.001 Thyroid cancer p<0.001 Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA056892	HPA059910

GENE INFORMATION
Gene name	GFPT2 (HGNC Symbol)
Synonyms	GFAT2
Description	Glutamine-fructose-6-phosphate transaminase 2 (HGNC Symbol)
Entrez gene summary
Chromosome	5
Cytoband	q35.3
Chromosome location (bp)	180300690 - 180353387
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000131459 (version 83.38)
Entrez gene	9945
UniProt	O94808 (UniProt - Evidence at protein level)
neXtProt	NX_O94808
Antibodypedia	GFPT2 antibodies

PROTEIN BROWSER

GFPT2-001	GFPT2-002	GFPT2-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GFPT2-001 ENSP00000253778 ENST00000253778	O94808 [Direct mapping] Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004360 [glutamine-fructose-6-phosphate transaminase (isomerizing) activity] GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0006002 [fructose 6-phosphate metabolic process] GO:0006047 [UDP-N-acetylglucosamine metabolic process] GO:0006048 [UDP-N-acetylglucosamine biosynthetic process] GO:0006112 [energy reserve metabolic process] GO:0006487 [protein N-linked glycosylation] GO:0006488 [dolichol-linked oligosaccharide biosynthetic process] GO:0006541 [glutamine metabolic process] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030246 [carbohydrate binding] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:1901137 [carbohydrate derivative biosynthetic process] Show all	682 aa 76.9 kDa	No	2
GFPT2-002 ENSP00000422771 ENST00000503228	D6RAC1 [Direct mapping] Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		179 aa 18.9 kDa	No	0
GFPT2-005 ENSP00000431125 ENST00000518906	E5RJP4 [Direct mapping] Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 Show all	SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		216 aa 24.4 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.