Tissue expression of PSMC3IP - Summary - The Human Protein Atlas

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PSMC3IP

TISSUE

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CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	PSMC3IP
Gene description	PSMC3 interacting protein
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (testis)
GTEx:	Tissue enriched (testis)
FANTOM5:	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression

Nuclear expression in testis.

DATA RELIABILITY
Data reliability description	Presumed off target binding observed and disregarded. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA044439
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (testis)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (testis)

GENE INFORMATION
Gene name	PSMC3IP (HGNC Symbol)
Synonyms	GT198, Hop2, HUMGT198A, TBPIP
Description	PSMC3 interacting protein (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that functions in meiotic recombination. It is a subunit of the PSMC3IP/MND1 complex, which interacts with PSMC3/TBP1 to stimulate DMC1- and RAD51-mediated strand exchange during meiosis. The protein encoded by this gene can also co-activate ligand-driven transcription mediated by estrogen, androgen, glucocorticoid, progesterone, and thyroid nuclear receptors. Mutations in this gene cause XX female gonadal dysgenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2011]
Chromosome	17
Cytoband	q21.2
Chromosome location (bp)	42572315 - 42577831
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000131470 (version 83.38)
Entrez gene	29893
UniProt	Q9P2W1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9P2W1
Antibodypedia	PSMC3IP antibodies

PROTEIN BROWSER

PSMC3IP-001	PSMC3IP-002	PSMC3IP-007	PSMC3IP-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PSMC3IP-001 ENSP00000253789 ENST00000253789	Q9P2W1 [Direct mapping] Homologous-pairing protein 2 homolog Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005575 [cellular_component] GO:0005634 [nucleus] GO:0006310 [DNA recombination] GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity] GO:0051321 [meiotic cell cycle] GO:1903506 [regulation of nucleic acid-templated transcription] Show all	205 aa 23.6 kDa	No	0
PSMC3IP-002 ENSP00000377384 ENST00000393795	Q9P2W1 [Direct mapping] Homologous-pairing protein 2 homolog Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005575 [cellular_component] GO:0005634 [nucleus] GO:0006310 [DNA recombination] GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity] GO:0051321 [meiotic cell cycle] GO:1903506 [regulation of nucleic acid-templated transcription] Show all	217 aa 24.9 kDa	No	0
PSMC3IP-007 ENSP00000468188 ENST00000587209	K7ERB6 [Direct mapping] Homologous-pairing protein 2 homolog; PSMC3 interacting protein, isoform CRA_b Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all		154 aa 18 kDa	No	0
PSMC3IP-008 ENSP00000466381 ENST00000590760	Q9P2W1 [Direct mapping] Homologous-pairing protein 2 homolog Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005575 [cellular_component] GO:0005634 [nucleus] GO:0006310 [DNA recombination] GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity] GO:0051321 [meiotic cell cycle] GO:1903506 [regulation of nucleic acid-templated transcription] Show all	92 aa 11.1 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.