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AOC2

GENERAL INFORMATION

Gene name

 AOC2

Gene description

 Amine oxidase, copper containing 2 (retina-specific)

Protein class

 Enzymes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (testis cancer)
HPA (cell line):Mixed
HPA (normal tissue):Tissue enhanced (adipose tissue, testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA057779
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable).
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (testis cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA057779

GENE INFORMATION

Gene name

 AOC2 (HGNC Symbol)

Synonyms

 DAO2, RAO

Description

 Amine oxidase, copper containing 2 (retina-specific) (HGNC Symbol)

Entrez gene summary

 Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. This gene shows high sequence similarity to copper amine oxidases from various species ranging from bacteria to mammals. The protein contains several conserved motifs including the active site of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine. This gene may be a candidate gene for hereditary ocular diseases. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q21.31

Chromosome location (bp)

 42844600 - 42850707

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000131480 (version 83.38)

Entrez gene

 314

UniProt

 O75106 (UniProt - Evidence at protein level)

neXtProt

 NX_O75106

Antibodypedia

 AOC2 antibodies

PROTEIN BROWSER
AOC2-001
AOC2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AOC2-001
ENSP00000253799
ENST00000253799
O75106 [Direct mapping]
Retina-specific copper amine oxidase
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Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
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GO:0005507 [copper ion binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006584 [catecholamine metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0007601 [visual perception]
GO:0008131 [primary amine oxidase activity]
GO:0009055 [electron carrier activity]
GO:0009308 [amine metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0048038 [quinone binding]
GO:0052593 [tryptamine:oxygen oxidoreductase (deaminating) activity]
GO:0052594 [aminoacetone:oxygen oxidoreductase(deaminating) activity]
GO:0052595 [aliphatic-amine oxidase activity]
GO:0052596 [phenethylamine:oxygen oxidoreductase (deaminating) activity]
GO:0055114 [oxidation-reduction process]
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 756 aa
83.7 kDa 		Yes 0
AOC2-002
ENSP00000406134
ENST00000452774
O75106 [Direct mapping]
Retina-specific copper amine oxidase
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Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0005507 [copper ion binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006584 [catecholamine metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0007601 [visual perception]
GO:0008131 [primary amine oxidase activity]
GO:0009055 [electron carrier activity]
GO:0009308 [amine metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0048038 [quinone binding]
GO:0052593 [tryptamine:oxygen oxidoreductase (deaminating) activity]
GO:0052594 [aminoacetone:oxygen oxidoreductase(deaminating) activity]
GO:0052595 [aliphatic-amine oxidase activity]
GO:0052596 [phenethylamine:oxygen oxidoreductase (deaminating) activity]
GO:0055114 [oxidation-reduction process]
Show all
 729 aa
80.5 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.