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G6PC

GENERAL INFORMATION

Gene name

 G6PC

Gene description

 Glucose-6-phosphatase, catalytic subunit

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (liver cancer)
HPA (cell line):Not detected
HPA (normal tissue):Tissue enhanced (kidney, liver)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in hepatocytes, renal tubules and gastrointestinal tract.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA052324
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and liver cancer (favourable).
Renal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA052324

GENE INFORMATION

Gene name

 G6PC (HGNC Symbol)

Synonyms

 G6PT, GSD1a

Description

 Glucose-6-phosphatase, catalytic subunit (HGNC Symbol)

Entrez gene summary

 Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. This gene (G6PC) is one of the three glucose-6-phosphatase catalytic-subunit-encoding genes in human: G6PC, G6PC2 and G6PC3. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). This disease, also known as von Gierke disease, is a metabolic disorder characterized by severe hypoglycemia associated with the accumulation of glycogen and fat in the liver and kidneys.[provided by RefSeq, Feb 2011]

Chromosome

 17

Cytoband

 q21.31

Chromosome location (bp)

 42900797 - 42913369

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000131482 (version 83.38)

Entrez gene

 2538

UniProt

 P35575 (UniProt - Evidence at protein level)

neXtProt

 NX_P35575

Antibodypedia

 G6PC antibodies

PROTEIN BROWSER
G6PC-001
G6PC-002
G6PC-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
G6PC-001
ENSP00000253801
ENST00000253801
P35575 [Direct mapping]
Glucose-6-phosphatase
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Disease related genes
Potential drug targets
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GO:0004346 [glucose-6-phosphatase activity]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0005977 [glycogen metabolic process]
GO:0005980 [glycogen catabolic process]
GO:0006094 [gluconeogenesis]
GO:0006641 [triglyceride metabolic process]
GO:0006796 [phosphate-containing compound metabolic process]
GO:0008202 [steroid metabolic process]
GO:0008645 [hexose transport]
GO:0010468 [regulation of gene expression]
GO:0015758 [glucose transport]
GO:0015760 [glucose-6-phosphate transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0032094 [response to food]
GO:0035264 [multicellular organism growth]
GO:0042301 [phosphate ion binding]
GO:0042593 [glucose homeostasis]
GO:0042632 [cholesterol homeostasis]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
GO:0046415 [urate metabolic process]
GO:0046838 [phosphorylated carbohydrate dephosphorylation]
GO:0051156 [glucose 6-phosphate metabolic process]
GO:0055085 [transmembrane transport]
GO:0055088 [lipid homeostasis]
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 357 aa
40.5 kDa 		No 8
G6PC-002
ENSP00000465958
ENST00000592383
P35575 [Direct mapping]
Glucose-6-phosphatase
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Disease related genes
Potential drug targets
Show all
GO:0004346 [glucose-6-phosphatase activity]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0005977 [glycogen metabolic process]
GO:0006094 [gluconeogenesis]
GO:0008645 [hexose transport]
GO:0015758 [glucose transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0042301 [phosphate ion binding]
GO:0042593 [glucose homeostasis]
GO:0044281 [small molecule metabolic process]
GO:0051156 [glucose 6-phosphate metabolic process]
GO:0055085 [transmembrane transport]
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 176 aa
20.2 kDa 		No 3
G6PC-003
ENSP00000466202
ENST00000585489
K7ELS6 [Direct mapping]
Glucose-6-phosphatase
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Show all
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0051156 [glucose 6-phosphate metabolic process]
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 163 aa
19 kDa 		No 3

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.