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UBE2D2

GENERAL INFORMATION

Gene name

 UBE2D2

Gene description

 Ubiquitin-conjugating enzyme E2D 2

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear membranous expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Approved based on 1 antibody.
HPA003920
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), renal cancer (unfavourable), colorectal cancer (favourable) and endometrial cancer (favourable).
Liver cancer p<0.001
Renal cancer p<0.001
Colorectal cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA003920

GENE INFORMATION

Gene name

 UBE2D2 (HGNC Symbol)

Synonyms

 UBC4, UbcH5B

Description

 Ubiquitin-conjugating enzyme E2D 2 (HGNC Symbol)

Entrez gene summary

 Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

Chromosome

 5

Cytoband

 q31.2

Chromosome location (bp)

 139526431 - 139628433

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000131508 (version 83.38)

Entrez gene

 7322

UniProt

 P62837 (UniProt - Evidence at protein level)

neXtProt

 NX_P62837

Antibodypedia

 UBE2D2 antibodies

PROTEIN BROWSER
UBE2D2-001
UBE2D2-002
UBE2D2-003
UBE2D2-006
UBE2D2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UBE2D2-001
ENSP00000381717
ENST00000398733
P62837 [Direct mapping]
Ubiquitin-conjugating enzyme E2 D2
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Enzymes
   ENZYME proteins
   Transferases
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000209 [protein polyubiquitination]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006464 [cellular protein modification process]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0016567 [protein ubiquitination]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043234 [protein complex]
GO:0045087 [innate immune response]
GO:0050852 [T cell receptor signaling pathway]
GO:0051865 [protein autoubiquitination]
GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0061631 [ubiquitin conjugating enzyme activity]
GO:0070062 [extracellular exosome]
GO:0070936 [protein K48-linked ubiquitination]
GO:0071456 [cellular response to hypoxia]
Show all
 147 aa
16.7 kDa 		No 0
UBE2D2-002
ENSP00000424941
ENST00000505548
P62837 [Direct mapping]
Ubiquitin-conjugating enzyme E2 D2
Show all
Enzymes
   ENZYME proteins
   Transferases
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Plasma proteins
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000209 [protein polyubiquitination]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006464 [cellular protein modification process]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0016567 [protein ubiquitination]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043234 [protein complex]
GO:0045087 [innate immune response]
GO:0050852 [T cell receptor signaling pathway]
GO:0051865 [protein autoubiquitination]
GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0061631 [ubiquitin conjugating enzyme activity]
GO:0070062 [extracellular exosome]
GO:0070936 [protein K48-linked ubiquitination]
GO:0071456 [cellular response to hypoxia]
Show all
 118 aa
13.6 kDa 		No 0
UBE2D2-003
ENSP00000426523
ENST00000505007
D6RFM0 [Direct mapping]
Ubiquitin-conjugating enzyme E2 D2
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Predicted intracellular proteins
Show all
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016874 [ligase activity]
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 98 aa
11.1 kDa 		No 0
UBE2D2-006
ENSP00000429613
ENST00000511725
P62837 [Direct mapping]
Ubiquitin-conjugating enzyme E2 D2
Show all
Enzymes
   ENZYME proteins
   Transferases
Transporters
   Primary Active Transporters
Predicted intracellular proteins
Plasma proteins
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000209 [protein polyubiquitination]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006464 [cellular protein modification process]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0016567 [protein ubiquitination]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043234 [protein complex]
GO:0045087 [innate immune response]
GO:0050852 [T cell receptor signaling pathway]
GO:0051865 [protein autoubiquitination]
GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0061631 [ubiquitin conjugating enzyme activity]
GO:0070062 [extracellular exosome]
GO:0070936 [protein K48-linked ubiquitination]
GO:0071456 [cellular response to hypoxia]
Show all
 118 aa
13.6 kDa 		No 0
UBE2D2-201
ENSP00000253815
ENST00000253815
A0A0A0MQU3 [Direct mapping]
Ubiquitin-conjugating enzyme E2 D2
Show all
Predicted intracellular proteins
Show all
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016874 [ligase activity]
Show all
 147 aa
16.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.