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EXOC4

GENERAL INFORMATION

Gene name

 EXOC4

Gene description

 Exocyst complex component 4

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA031443
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and pancreatic cancer (unfavourable).
Renal cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA031443

GENE INFORMATION

Gene name

 EXOC4 (HGNC Symbol)

Synonyms

 KIAA1699, MGC27170, SEC8, SEC8L1, Sec8p

Description

 Exocyst complex component 4 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q33

Chromosome location (bp)

 133253073 - 134066589

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000131558 (version 83.38)

Entrez gene

 60412

UniProt

 Q96A65 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96A65

Antibodypedia

 EXOC4 antibodies

PROTEIN BROWSER
EXOC4-001
EXOC4-025

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EXOC4-001
ENSP00000253861
ENST00000253861
Q96A65 [Direct mapping]
Exocyst complex component 4
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000145 [exocyst]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005902 [microvillus]
GO:0006904 [vesicle docking involved in exocytosis]
GO:0006996 [organelle organization]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0017160 [Ral GTPase binding]
GO:0030165 [PDZ domain binding]
GO:0032584 [growth cone membrane]
GO:0035748 [myelin sheath abaxonal region]
GO:0044267 [cellular protein metabolic process]
GO:0047485 [protein N-terminus binding]
GO:0048341 [paraxial mesoderm formation]
GO:0061024 [membrane organization]
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 974 aa
110.5 kDa 		No 0
EXOC4-025
ENSP00000376868
ENST00000393161
Q96A65 [Direct mapping]
Exocyst complex component 4
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000145 [exocyst]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006904 [vesicle docking involved in exocytosis]
GO:0006996 [organelle organization]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0017160 [Ral GTPase binding]
GO:0044267 [cellular protein metabolic process]
GO:0047485 [protein N-terminus binding]
GO:0061024 [membrane organization]
Show all
 473 aa
53.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.