Expression of C1orf159 in cancer - Summary - The Human Protein Atlas

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C1orf159

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	C1orf159
Gene description	Chromosome 1 open reading frame 159
Protein class	Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA010019
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable) and urothelial cancer (favourable).
Renal cancer p<0.001 Liver cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA010019

GENE INFORMATION
Gene name	C1orf159 (HGNC Symbol)
Synonyms	FLJ20584
Description	Chromosome 1 open reading frame 159 (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	p36.33
Chromosome location (bp)	1081818 - 1116361
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000131591 (version 83.38)
Entrez gene	54991
UniProt	Q96HA4 (UniProt - Evidence at transcript level)
neXtProt	NX_Q96HA4
Antibodypedia	C1orf159 antibodies

PROTEIN BROWSER

C1orf159-001	C1orf159-002	C1orf159-004	C1orf159-007	C1orf159-008	C1orf159-009	C1orf159-011	C1orf159-015	C1orf159-016	C1orf159-017

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C1orf159-001 ENSP00000400736 ENST00000421241	Q96HA4 [Direct mapping] Uncharacterized protein C1orf159 A0A024R082 [Target identity:100%; Query identity:100%] Chromosome 1 open reading frame 159, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	198 aa 20.8 kDa	Yes	1
C1orf159-002 ENSP00000368644 ENST00000379339	Q96HA4 [Direct mapping] Uncharacterized protein C1orf159 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	380 aa 40.3 kDa	Yes	1
C1orf159-004 ENSP00000368624 ENST00000379320	Q5T2W9 [Direct mapping] Uncharacterized protein C1orf159 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	344 aa 36.5 kDa	Yes	1
C1orf159-007 ENSP00000462517 ENST00000475119	J3KSJ6 [Direct mapping] Uncharacterized protein C1orf159 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		86 aa 8.7 kDa	Yes	0
C1orf159-008 ENSP00000464273 ENST00000462097	J3QRL0 [Direct mapping] Uncharacterized protein C1orf159 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		103 aa 10.5 kDa	Yes	0
C1orf159-009 ENSP00000368623 ENST00000379319	Q96HA4 [Direct mapping] Uncharacterized protein C1orf159 A0A024R082 [Target identity:100%; Query identity:100%] Chromosome 1 open reading frame 159, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	198 aa 20.8 kDa	Yes	1
C1orf159-011 ENSP00000390635 ENST00000434641	Q5T2W7 [Direct mapping] Uncharacterized protein C1orf159 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	224 aa 23.3 kDa	Yes	1
C1orf159-015 ENSP00000464657 ENST00000480643	J3QSF0 [Direct mapping] Uncharacterized protein C1orf159 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all		15 aa 1.5 kDa	No	0
C1orf159-016 ENSP00000395935 ENST00000427787	B2REC5 [Direct mapping] Uncharacterized protein C1orf159 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		64 aa 6.5 kDa	Yes	0
C1orf159-017 ENSP00000416740 ENST00000442117	B2REC4 [Direct mapping] Uncharacterized protein C1orf159 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		57 aa 5.9 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.