Expression of ANO1 in cancer - Summary - The Human Protein Atlas

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ANO1

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ANO1
Gene description	Anoctamin 1, calcium activated chloride channel
Protein class	FDA approved drug targets Plasma proteins Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Group enriched (A-431, CAPAN-2, HaCaT)
HPA (normal tissue):	Tissue enhanced (epididymis, seminal vesicle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA032148
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), endometrial cancer (favourable), head and neck cancer (unfavourable), pancreatic cancer (unfavourable) and lung cancer (unfavourable).
Renal cancer p<0.001 Endometrial cancer p<0.001 Head and neck cancer p<0.001 Pancreatic cancer p<0.001 Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA032148

GENE INFORMATION
Gene name	ANO1 (HGNC Symbol)
Synonyms	DOG1, FLJ10261, ORAOV2, TAOS2, TMEM16A
Description	Anoctamin 1, calcium activated chloride channel (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	q13.3
Chromosome location (bp)	70078302 - 70189528
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000131620 (version 83.38)
Entrez gene	55107
UniProt	Q5XXA6 (UniProt - Evidence at protein level)
neXtProt	NX_Q5XXA6
Antibodypedia	ANO1 antibodies

PROTEIN BROWSER

ANO1-001	ANO1-002	ANO1-003	ANO1-004	ANO1-006	ANO1-007	ANO1-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ANO1-001 ENSP00000347454 ENST00000355303	Q5XXA6 [Direct mapping] Anoctamin-1 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005227 [calcium activated cation channel activity] GO:0005229 [intracellular calcium activated chloride channel activity] GO:0005247 [voltage-gated chloride channel activity] GO:0005254 [chloride channel activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006812 [cation transport] GO:0006821 [chloride transport] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007275 [multicellular organismal development] GO:0009897 [external side of plasma membrane] GO:0015111 [iodide transmembrane transporter activity] GO:0015705 [iodide transport] GO:0016324 [apical plasma membrane] GO:0034220 [ion transmembrane transport] GO:0034605 [cellular response to heat] GO:0034707 [chloride channel complex] GO:0035774 [positive regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0042391 [regulation of membrane potential] GO:0042803 [protein homodimerization activity] GO:0046982 [protein heterodimerization activity] GO:0050965 [detection of temperature stimulus involved in sensory perception of pain] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0098655 [cation transmembrane transport] GO:1902476 [chloride transmembrane transport] GO:1903959 [regulation of anion transmembrane transport] Show all	986 aa 114.1 kDa	No	8
ANO1-002 ENSP00000319477 ENST00000316296	Q5XXA6 [Direct mapping] Anoctamin-1 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0005227 [calcium activated cation channel activity] GO:0005229 [intracellular calcium activated chloride channel activity] GO:0005247 [voltage-gated chloride channel activity] GO:0005254 [chloride channel activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006812 [cation transport] GO:0006821 [chloride transport] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007275 [multicellular organismal development] GO:0015111 [iodide transmembrane transporter activity] GO:0015705 [iodide transport] GO:0016324 [apical plasma membrane] GO:0034220 [ion transmembrane transport] GO:0034605 [cellular response to heat] GO:0034707 [chloride channel complex] GO:0035774 [positive regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0050965 [detection of temperature stimulus involved in sensory perception of pain] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0098655 [cation transmembrane transport] GO:1902476 [chloride transmembrane transport] GO:1903959 [regulation of anion transmembrane transport] Show all	642 aa 74.4 kDa	No	5
ANO1-003 ENSP00000435797 ENST00000530676	Q5XXA6 [Direct mapping] Anoctamin-1 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0005227 [calcium activated cation channel activity] GO:0005229 [intracellular calcium activated chloride channel activity] GO:0005247 [voltage-gated chloride channel activity] GO:0005254 [chloride channel activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006812 [cation transport] GO:0006821 [chloride transport] GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway] GO:0007275 [multicellular organismal development] GO:0015111 [iodide transmembrane transporter activity] GO:0015705 [iodide transport] GO:0016324 [apical plasma membrane] GO:0034220 [ion transmembrane transport] GO:0034605 [cellular response to heat] GO:0034707 [chloride channel complex] GO:0035774 [positive regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0050965 [detection of temperature stimulus involved in sensory perception of pain] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0098655 [cation transmembrane transport] GO:1902476 [chloride transmembrane transport] GO:1903959 [regulation of anion transmembrane transport] Show all	840 aa 97.7 kDa	No	8
ANO1-004 ENSP00000432843 ENST00000531349	E9PNA7 [Direct mapping] Anoctamin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0034605 [cellular response to heat] GO:0035774 [positive regulation of insulin secretion involved in cellular response to glucose stimulus] GO:1902476 [chloride transmembrane transport] Show all	695 aa 80.4 kDa	No	8
ANO1-006 ENSP00000436392 ENST00000531604	E9PP68 [Direct mapping] Anoctamin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0034605 [cellular response to heat] GO:0035774 [positive regulation of insulin secretion involved in cellular response to glucose stimulus] GO:1902476 [chloride transmembrane transport] Show all	251 aa 28.7 kDa	No	0
ANO1-007 ENSP00000433445 ENST00000530480	H0YDD9 [Direct mapping] Anoctamin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0034605 [cellular response to heat] GO:0035774 [positive regulation of insulin secretion involved in cellular response to glucose stimulus] GO:1902476 [chloride transmembrane transport] Show all	269 aa 31 kDa	No	1
ANO1-008 ENSP00000435868 ENST00000531300	E9PS90 [Direct mapping] Anoctamin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0034605 [cellular response to heat] GO:0035774 [positive regulation of insulin secretion involved in cellular response to glucose stimulus] GO:1902476 [chloride transmembrane transport] Show all	151 aa 17.5 kDa	No	2

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