Expression of KREMEN2 in cancer - Summary - The Human Protein Atlas

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KREMEN2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	KREMEN2
Gene description	Kringle containing transmembrane protein 2
Protein class	Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (HMC-1, RPMI-8226)
HPA (normal tissue):	Tissue enhanced (skin)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA003223
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PROGNOSTIC SUMMARY
Prognostic marker in lung cancer (unfavourable).
Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA003223

GENE INFORMATION
Gene name	KREMEN2 (HGNC Symbol)
Synonyms	KRM2, MGC10791
Description	Kringle containing transmembrane protein 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse functions interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Chromosome	16
Cytoband	p13.3
Chromosome location (bp)	2963944 - 2968383
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000131650 (version 83.38)
Entrez gene	79412
UniProt	Q8NCW0 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8NCW0
Antibodypedia	KREMEN2 antibodies

PROTEIN BROWSER

KREMEN2-001	KREMEN2-002	KREMEN2-003	KREMEN2-004	KREMEN2-005	KREMEN2-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KREMEN2-001 ENSP00000304422 ENST00000303746	Q8NCW0 [Direct mapping] Kremen protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007154 [cell communication] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016055 [Wnt signaling pathway] GO:0031901 [early endosome membrane] GO:0090090 [negative regulation of canonical Wnt signaling pathway] Show all	462 aa 48.8 kDa	Yes	1
KREMEN2-002 ENSP00000322079 ENST00000319500	Q8NCW0 [Direct mapping] Kremen protein 2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005886 [plasma membrane] GO:0007154 [cell communication] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016055 [Wnt signaling pathway] GO:0031901 [early endosome membrane] GO:0090090 [negative regulation of canonical Wnt signaling pathway] Show all	420 aa 44.4 kDa	Yes	0
KREMEN2-003 ENSP00000459878 ENST00000575885	Q8NCW0 [Direct mapping] Kremen protein 2 A0A0A6YYC9 [Direct mapping] Kremen protein 2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005886 [plasma membrane] GO:0007154 [cell communication] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016055 [Wnt signaling pathway] GO:0031901 [early endosome membrane] GO:0090090 [negative regulation of canonical Wnt signaling pathway] Show all	381 aa 40.4 kDa	Yes	0
KREMEN2-004 ENSP00000461860 ENST00000571007	Q8NCW0 [Direct mapping] Kremen protein 2 A0A0A6YYD0 [Direct mapping] Kremen protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005886 [plasma membrane] GO:0007154 [cell communication] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016055 [Wnt signaling pathway] GO:0031901 [early endosome membrane] GO:0090090 [negative regulation of canonical Wnt signaling pathway] Show all	423 aa 44.9 kDa	Yes	1
KREMEN2-005 ENSP00000460578 ENST00000572045	Q8NCW0 [Direct mapping] Kremen protein 2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005886 [plasma membrane] GO:0007154 [cell communication] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016055 [Wnt signaling pathway] GO:0031901 [early endosome membrane] GO:0090090 [negative regulation of canonical Wnt signaling pathway] Show all	399 aa 42 kDa	Yes	0
KREMEN2-006 ENSP00000460917 ENST00000575769	Q8NCW0 [Direct mapping] Kremen protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005886 [plasma membrane] GO:0007154 [cell communication] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016055 [Wnt signaling pathway] GO:0031901 [early endosome membrane] GO:0090090 [negative regulation of canonical Wnt signaling pathway] Show all	424 aa 45.1 kDa	Yes	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.