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THOC6

GENERAL INFORMATION

Gene name

 THOC6

Gene description

 THO complex 6

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly nuclear expression in all tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA052953
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA052953

GENE INFORMATION

Gene name

 THOC6 (HGNC Symbol)

Synonyms

 fSAP35, MGC2655, WDR58

Description

 THO complex 6 (HGNC Symbol)

Entrez gene summary

Chromosome

 16

Cytoband

 p13.3

Chromosome location (bp)

 3024027 - 3027755

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000131652 (version 83.38)

Entrez gene

 79228

UniProt

 Q86W42 (UniProt - Evidence at protein level)

neXtProt

 NX_Q86W42

Antibodypedia

 THOC6 antibodies

PROTEIN BROWSER
THOC6-001
THOC6-002
THOC6-005
THOC6-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
THOC6-001
ENSP00000458295
ENST00000574549
Q86W42 [Direct mapping]
THO complex subunit 6 homolog
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Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
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GO:0000346 [transcription export complex]
GO:0000347 [THO complex]
GO:0000445 [THO complex part of transcription export complex]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006397 [mRNA processing]
GO:0006406 [mRNA export from nucleus]
GO:0006915 [apoptotic process]
GO:0007417 [central nervous system development]
GO:0008380 [RNA splicing]
GO:0016607 [nuclear speck]
GO:0043066 [negative regulation of apoptotic process]
GO:0046784 [viral mRNA export from host cell nucleus]
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 317 aa
34.8 kDa 		No 0
THOC6-002
ENSP00000326531
ENST00000326266
Q86W42 [Direct mapping]
THO complex subunit 6 homolog
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000346 [transcription export complex]
GO:0000347 [THO complex]
GO:0000445 [THO complex part of transcription export complex]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006397 [mRNA processing]
GO:0006406 [mRNA export from nucleus]
GO:0006915 [apoptotic process]
GO:0007417 [central nervous system development]
GO:0008380 [RNA splicing]
GO:0016607 [nuclear speck]
GO:0043066 [negative regulation of apoptotic process]
GO:0046784 [viral mRNA export from host cell nucleus]
Show all
 341 aa
37.5 kDa 		No 0
THOC6-005
ENSP00000460015
ENST00000575576
Q86W42 [Direct mapping]
THO complex subunit 6 homolog
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000346 [transcription export complex]
GO:0000347 [THO complex]
GO:0000445 [THO complex part of transcription export complex]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006397 [mRNA processing]
GO:0006406 [mRNA export from nucleus]
GO:0006915 [apoptotic process]
GO:0007417 [central nervous system development]
GO:0008380 [RNA splicing]
GO:0016607 [nuclear speck]
GO:0043066 [negative regulation of apoptotic process]
GO:0046784 [viral mRNA export from host cell nucleus]
Show all
 317 aa
34.8 kDa 		No 0
THOC6-006
ENSP00000253952
ENST00000253952
Q86W42 [Direct mapping]
THO complex subunit 6 homolog
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000346 [transcription export complex]
GO:0000347 [THO complex]
GO:0000445 [THO complex part of transcription export complex]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006397 [mRNA processing]
GO:0006406 [mRNA export from nucleus]
GO:0006915 [apoptotic process]
GO:0007417 [central nervous system development]
GO:0008380 [RNA splicing]
GO:0016607 [nuclear speck]
GO:0043066 [negative regulation of apoptotic process]
GO:0046784 [viral mRNA export from host cell nucleus]
Show all
 296 aa
32.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.