Expression of CKMT2 in cancer - Summary - The Human Protein Atlas

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CKMT2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CKMT2
Gene description	Creatine kinase, mitochondrial 2 (sarcomeric)
Protein class	Enzymes FDA approved drug targets Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Group enriched (BEWO, HEK93, Hep G2, T-47d)
HPA (normal tissue):	Group enriched (heart muscle, skeletal muscle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in heart and skeletal muscle.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA051880
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA051880

GENE INFORMATION
Gene name	CKMT2 (HGNC Symbol)
Synonyms	SMTCK
Description	Creatine kinase, mitochondrial 2 (sarcomeric) (HGNC Symbol)
Entrez gene summary	Mitochondrial creatine kinase (MtCK) is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Sarcomeric mitochondrial creatine kinase has 80% homology with the coding exons of ubiquitous mitochondrial creatine kinase. This gene contains sequences homologous to several motifs that are shared among some nuclear genes encoding mitochondrial proteins and thus may be essential for the coordinated activation of these genes during mitochondrial biogenesis. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q14.1
Chromosome location (bp)	81233285 - 81266397
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000131730 (version 83.38)
Entrez gene	1160
UniProt	P17540 (UniProt - Evidence at protein level)
neXtProt	NX_P17540
Antibodypedia	CKMT2 antibodies

PROTEIN BROWSER

CKMT2-001	CKMT2-003	CKMT2-004	CKMT2-007	CKMT2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CKMT2-001 ENSP00000254035 ENST00000254035	P17540 [Direct mapping] Creatine kinase S-type, mitochondrial A0A024RAK5 [Target identity:100%; Query identity:100%] Creatine kinase, mitochondrial 2 (Sarcomeric), isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0004111 [creatine kinase activity] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006595 [polyamine metabolic process] GO:0006600 [creatine metabolic process] GO:0006936 [muscle contraction] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] Show all	419 aa 47.5 kDa	No	0
CKMT2-003 ENSP00000404203 ENST00000424301	P17540 [Direct mapping] Creatine kinase S-type, mitochondrial A0A024RAK5 [Target identity:100%; Query identity:100%] Creatine kinase, mitochondrial 2 (Sarcomeric), isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004111 [creatine kinase activity] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006595 [polyamine metabolic process] GO:0006600 [creatine metabolic process] GO:0006936 [muscle contraction] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] Show all	419 aa 47.5 kDa	No	0
CKMT2-004 ENSP00000423264 ENST00000511719	D6R998 [Direct mapping] Creatine kinase S-type, mitochondrial Show all	Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups] Show all	170 aa 19 kDa	No	0
CKMT2-007 ENSP00000427635 ENST00000505060	D6RHV3 [Direct mapping] Creatine kinase S-type, mitochondrial Show all	Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups] Show all	158 aa 17.7 kDa	No	0
CKMT2-201 ENSP00000410289 ENST00000437669	P17540 [Direct mapping] Creatine kinase S-type, mitochondrial A0A024RAK5 [Target identity:100%; Query identity:100%] Creatine kinase, mitochondrial 2 (Sarcomeric), isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004111 [creatine kinase activity] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006595 [polyamine metabolic process] GO:0006600 [creatine metabolic process] GO:0006936 [muscle contraction] GO:0016301 [kinase activity] GO:0016310 [phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] Show all	419 aa 47.5 kDa	No	0

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The Human Protein Atlas

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