Expression of KRT34 in cancer - Summary - The Human Protein Atlas

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KRT34

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	KRT34
Gene description	Keratin 34, type I
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (head and neck cancer)
HPA (cell line):	Cell line enhanced (BJ, BJ hTERT+ SV40 Large T+ RasG12V, HBF TERT88)
HPA (normal tissue):	Tissue enriched (cervix, uterine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Highly expressed in hair follicle cortex.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene. External characterization data supports antibody staining.
Reliability score	Supported based on 2 antibodies. HPA055194 , HPA072208
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (head and neck cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA055194	HPA072208

GENE INFORMATION
Gene name	KRT34 (HGNC Symbol)
Synonyms	Ha-4, KRTHA4
Description	Keratin 34, type I (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q21.2
Chromosome location (bp)	41377650 - 41382403
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000131737 (version 83.38)
Entrez gene	3885
UniProt	O76011 (UniProt - Evidence at transcript level)
neXtProt	NX_O76011
Antibodypedia	KRT34 antibodies

PROTEIN BROWSER

KRT34-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KRT34-001 ENSP00000377570 ENST00000394001	O76011 [Direct mapping] Keratin, type I cuticular Ha4 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005615 [extracellular space] GO:0005882 [intermediate filament] GO:0008544 [epidermis development] GO:0070062 [extracellular exosome] Show all	436 aa 49.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.