Expression of KRT33B in cancer - Summary - The Human Protein Atlas

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KRT33B

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	KRT33B
Gene description	Keratin 33B, type I
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (urothelial cancer)
HPA (cell line):	Cell line enhanced (BJ, U-2197)
HPA (normal tissue):	Not detected

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Highly expressed in hair follicle cortex.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene. External characterization data supports antibody staining pattern while RNA data does not.
Reliability score	Supported based on 1 antibody. HPA055194
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (urothelial cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA055194

GENE INFORMATION
Gene name	KRT33B (HGNC Symbol)
Synonyms	Ha-3II, KRTHA3B
Description	Keratin 33B, type I (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the keratin gene family. This gene is one of multiple type I hair keratin genes that are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. As a type I hair keratin, the encoded protein is an acidic protein which heterodimerizes with type II keratins to form hair and nails. There are two isoforms of this protein, encoded by two separate genes, keratin 33A and keratin 33B. [provided by RefSeq, May 2012]
Chromosome	17
Cytoband	q21.2
Chromosome location (bp)	41363494 - 41369800
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000131738 (version 83.38)
Entrez gene	3884
UniProt	Q14525 (UniProt - Evidence at protein level)
neXtProt	NX_Q14525
Antibodypedia	KRT33B antibodies

PROTEIN BROWSER

KRT33B-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KRT33B-001 ENSP00000251646 ENST00000251646	Q14525 [Direct mapping] Keratin, type I cuticular Ha3-II Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005882 [intermediate filament] GO:0007568 [aging] GO:0042633 [hair cycle] GO:0070062 [extracellular exosome] Show all	404 aa 46.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.