Fields »
ABOUT
HELP
BLOG
RARA

GENERAL INFORMATION

Gene name

 RARA

Gene description

 Retinoic acid receptor, alpha

Protein class

 Cancer-related genes
Disease related genes
FDA approved drug targets
Nuclear receptors
Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 RARA (HGNC Symbol)

Synonyms

 NR1B1, RAR

Description

 Retinoic acid receptor, alpha (HGNC Symbol)

Entrez gene summary

 This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010]

Chromosome

 17

Cytoband

 q21.2

Chromosome location (bp)

 40309192 - 40357643

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000131759 (version 83.38)

Entrez gene

 5914

UniProt

 P10276 (UniProt - Evidence at protein level)

neXtProt

 NX_P10276

Antibodypedia

 RARA antibodies

PROTEIN BROWSER
RARA-001
RARA-002
RARA-003
RARA-004
RARA-005
RARA-007
RARA-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RARA-001
ENSP00000254066
ENST00000254066
P10276 [Direct mapping]
Retinoic acid receptor alpha
Q6I9R7 [Target identity:100%; Query identity:100%]
RARA protein; Retinoic acid nuclear receptor alpha variant 1; Retinoic acid receptor, alpha, isoform CRA_c; cDNA, FLJ92939, Homo sapiens retinoic acid receptor, alpha (RARA), mRNA
Show all
Nuclear receptors
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0000900 [translation repressor activity, nucleic acid binding]
GO:0000975 [regulatory region DNA binding]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001012 [RNA polymerase II regulatory region DNA binding]
GO:0001657 [ureteric bud development]
GO:0001843 [neural tube closure]
GO:0001889 [liver development]
GO:0001972 [retinoic acid binding]
GO:0002068 [glandular epithelial cell development]
GO:0003148 [outflow tract septum morphogenesis]
GO:0003417 [growth plate cartilage development]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003708 [retinoic acid receptor activity]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007281 [germ cell development]
GO:0007283 [spermatogenesis]
GO:0007565 [female pregnancy]
GO:0008134 [transcription factor binding]
GO:0008144 [drug binding]
GO:0008270 [zinc ion binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008584 [male gonad development]
GO:0009986 [cell surface]
GO:0010467 [gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0015629 [actin cytoskeleton]
GO:0017148 [negative regulation of translation]
GO:0019899 [enzyme binding]
GO:0019904 [protein domain specific binding]
GO:0021766 [hippocampus development]
GO:0030425 [dendrite]
GO:0030850 [prostate gland development]
GO:0030852 [regulation of granulocyte differentiation]
GO:0030853 [negative regulation of granulocyte differentiation]
GO:0031076 [embryonic camera-type eye development]
GO:0031490 [chromatin DNA binding]
GO:0031641 [regulation of myelination]
GO:0032355 [response to estradiol]
GO:0032526 [response to retinoic acid]
GO:0032689 [negative regulation of interferon-gamma production]
GO:0032720 [negative regulation of tumor necrosis factor production]
GO:0032736 [positive regulation of interleukin-13 production]
GO:0032753 [positive regulation of interleukin-4 production]
GO:0032754 [positive regulation of interleukin-5 production]
GO:0033189 [response to vitamin A]
GO:0034097 [response to cytokine]
GO:0035264 [multicellular organism growth]
GO:0042826 [histone deacetylase binding]
GO:0042981 [regulation of apoptotic process]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043066 [negative regulation of apoptotic process]
GO:0043277 [apoptotic cell clearance]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043422 [protein kinase B binding]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044323 [retinoic acid-responsive element binding]
GO:0045471 [response to ethanol]
GO:0045596 [negative regulation of cell differentiation]
GO:0045630 [positive regulation of T-helper 2 cell differentiation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045787 [positive regulation of cell cycle]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0045947 [negative regulation of translational initiation]
GO:0046982 [protein heterodimerization activity]
GO:0048027 [mRNA 5'-UTR binding]
GO:0048167 [regulation of synaptic plasticity]
GO:0048384 [retinoic acid receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051018 [protein kinase A binding]
GO:0051099 [positive regulation of binding]
GO:0051393 [alpha-actinin binding]
GO:0055012 [ventricular cardiac muscle cell differentiation]
GO:0060010 [Sertoli cell fate commitment]
GO:0060173 [limb development]
GO:0060324 [face development]
GO:0060348 [bone development]
GO:0060534 [trachea cartilage development]
GO:0060591 [chondroblast differentiation]
GO:0061037 [negative regulation of cartilage development]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071300 [cellular response to retinoic acid]
GO:0071391 [cellular response to estrogen stimulus]
Show all
 462 aa
50.8 kDa 		No 0
RARA-002
ENSP00000377649
ENST00000394089
P10276 [Direct mapping]
Retinoic acid receptor alpha
Q6I9R7 [Target identity:100%; Query identity:100%]
RARA protein; Retinoic acid nuclear receptor alpha variant 1; Retinoic acid receptor, alpha, isoform CRA_c; cDNA, FLJ92939, Homo sapiens retinoic acid receptor, alpha (RARA), mRNA
Show all
Nuclear receptors
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0000790 [nuclear chromatin]
GO:0001972 [retinoic acid binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003708 [retinoic acid receptor activity]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0009986 [cell surface]
GO:0010467 [gene expression]
GO:0015629 [actin cytoskeleton]
GO:0019899 [enzyme binding]
GO:0019904 [protein domain specific binding]
GO:0030853 [negative regulation of granulocyte differentiation]
GO:0031490 [chromatin DNA binding]
GO:0032526 [response to retinoic acid]
GO:0032689 [negative regulation of interferon-gamma production]
GO:0032720 [negative regulation of tumor necrosis factor production]
GO:0032736 [positive regulation of interleukin-13 production]
GO:0032753 [positive regulation of interleukin-4 production]
GO:0032754 [positive regulation of interleukin-5 production]
GO:0043277 [apoptotic cell clearance]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043422 [protein kinase B binding]
GO:0043565 [sequence-specific DNA binding]
GO:0044323 [retinoic acid-responsive element binding]
GO:0045630 [positive regulation of T-helper 2 cell differentiation]
GO:0045787 [positive regulation of cell cycle]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0048384 [retinoic acid receptor signaling pathway]
GO:0051018 [protein kinase A binding]
GO:0051099 [positive regulation of binding]
GO:0051393 [alpha-actinin binding]
GO:0071300 [cellular response to retinoic acid]
GO:0071391 [cellular response to estrogen stimulus]
Show all
 462 aa
50.8 kDa 		No 0
RARA-003
ENSP00000377648
ENST00000394086
A8MUP8 [Direct mapping]
Retinoic acid receptor alpha; Retinoic acid receptor, alpha, isoform CRA_e
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003708 [retinoic acid receptor activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0015629 [actin cytoskeleton]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0048384 [retinoic acid receptor signaling pathway]
Show all
 478 aa
52.9 kDa 		No 0
RARA-004
ENSP00000377643
ENST00000394081
P10276 [Direct mapping]
Retinoic acid receptor alpha
F1D8N9 [Target identity:100%; Query identity:100%]
Retinoic acid nuclear receptor alpha variant 2; Retinoic acid receptor, alpha, isoform CRA_b
Show all
Nuclear receptors
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0000790 [nuclear chromatin]
GO:0001972 [retinoic acid binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003708 [retinoic acid receptor activity]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0009986 [cell surface]
GO:0010467 [gene expression]
GO:0015629 [actin cytoskeleton]
GO:0019899 [enzyme binding]
GO:0019904 [protein domain specific binding]
GO:0030853 [negative regulation of granulocyte differentiation]
GO:0031490 [chromatin DNA binding]
GO:0032526 [response to retinoic acid]
GO:0032689 [negative regulation of interferon-gamma production]
GO:0032720 [negative regulation of tumor necrosis factor production]
GO:0032736 [positive regulation of interleukin-13 production]
GO:0032753 [positive regulation of interleukin-4 production]
GO:0032754 [positive regulation of interleukin-5 production]
GO:0043277 [apoptotic cell clearance]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043422 [protein kinase B binding]
GO:0043565 [sequence-specific DNA binding]
GO:0044323 [retinoic acid-responsive element binding]
GO:0045630 [positive regulation of T-helper 2 cell differentiation]
GO:0045787 [positive regulation of cell cycle]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0048384 [retinoic acid receptor signaling pathway]
GO:0051018 [protein kinase A binding]
GO:0051099 [positive regulation of binding]
GO:0051393 [alpha-actinin binding]
GO:0071300 [cellular response to retinoic acid]
GO:0071391 [cellular response to estrogen stimulus]
Show all
 457 aa
50.7 kDa 		No 0
RARA-005
ENSP00000462514
ENST00000475125
J3KSJ4 [Direct mapping]
Retinoic acid receptor alpha
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003708 [retinoic acid receptor activity]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0048384 [retinoic acid receptor signaling pathway]
Show all
 186 aa
21.4 kDa 		No 0
RARA-007
ENSP00000389993
ENST00000425707
P10276 [Direct mapping]
Retinoic acid receptor alpha
Show all
Nuclear receptors
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0000790 [nuclear chromatin]
GO:0001972 [retinoic acid binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003708 [retinoic acid receptor activity]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0009986 [cell surface]
GO:0010467 [gene expression]
GO:0015629 [actin cytoskeleton]
GO:0019899 [enzyme binding]
GO:0019904 [protein domain specific binding]
GO:0030853 [negative regulation of granulocyte differentiation]
GO:0031490 [chromatin DNA binding]
GO:0032526 [response to retinoic acid]
GO:0032689 [negative regulation of interferon-gamma production]
GO:0032720 [negative regulation of tumor necrosis factor production]
GO:0032736 [positive regulation of interleukin-13 production]
GO:0032753 [positive regulation of interleukin-4 production]
GO:0032754 [positive regulation of interleukin-5 production]
GO:0043277 [apoptotic cell clearance]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043422 [protein kinase B binding]
GO:0044323 [retinoic acid-responsive element binding]
GO:0045630 [positive regulation of T-helper 2 cell differentiation]
GO:0045787 [positive regulation of cell cycle]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0048384 [retinoic acid receptor signaling pathway]
GO:0051018 [protein kinase A binding]
GO:0051099 [positive regulation of binding]
GO:0051393 [alpha-actinin binding]
GO:0071300 [cellular response to retinoic acid]
GO:0071391 [cellular response to estrogen stimulus]
Show all
 365 aa
39.7 kDa 		No 0
RARA-008
ENSP00000464287
ENST00000577646
J3QRM2 [Direct mapping]
Retinoic acid receptor alpha
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Show all
 66 aa
6.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.