Expression of PEX11B in cancer - Summary - The Human Protein Atlas

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PEX11B

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PEX11B
Gene description	Peroxisomal biogenesis factor 11 beta
Protein class	Disease related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, in some tissues with a granular pattern.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA050104
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and lung cancer (favourable).
Liver cancer p<0.001 Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA050104

GENE INFORMATION
Gene name	PEX11B
Synonyms
Description	Peroxisomal biogenesis factor 11 beta (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene facilitates peroxisomal proliferation and interacts with PEX19. The encoded protein is found in the peroxisomal membrane. Several transcript variants, some protein-coding and some not protein-coding, have been found for this gene. [provided by RefSeq, Dec 2012]
Chromosome	1
Cytoband	q21.1
Chromosome location (bp)	145911350 - 145918837
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000131779 (version 83.38)
Entrez gene	8799
UniProt	O96011 (UniProt - Evidence at protein level)
neXtProt	NX_O96011
Antibodypedia	PEX11B antibodies

PROTEIN BROWSER

PEX11B-001	PEX11B-002	PEX11B-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PEX11B-001 ENSP00000358312 ENST00000369306	O96011 [Direct mapping] Peroxisomal membrane protein 11B A0A024R4E7 [Target identity:100%; Query identity:100%] Peroxisomal biogenesis factor 11B, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005777 [peroxisome] GO:0005778 [peroxisomal membrane] GO:0005779 [integral component of peroxisomal membrane] GO:0007031 [peroxisome organization] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0016559 [peroxisome fission] GO:0042803 [protein homodimerization activity] GO:0043234 [protein complex] GO:0044375 [regulation of peroxisome size] GO:0051260 [protein homooligomerization] GO:0070062 [extracellular exosome] Show all	259 aa 28.4 kDa	No	1
PEX11B-002 ENSP00000414018 ENST00000428634	H7C3V6 [Direct mapping] Peroxisomal membrane protein 11B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005779 [integral component of peroxisomal membrane] GO:0016559 [peroxisome fission] Show all	81 aa 8.8 kDa	No	1
PEX11B-201 ENSP00000437510 ENST00000537888	O96011 [Direct mapping] Peroxisomal membrane protein 11B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005777 [peroxisome] GO:0005778 [peroxisomal membrane] GO:0005779 [integral component of peroxisomal membrane] GO:0007031 [peroxisome organization] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0016559 [peroxisome fission] GO:0042803 [protein homodimerization activity] GO:0043234 [protein complex] GO:0044375 [regulation of peroxisome size] GO:0051260 [protein homooligomerization] GO:0070062 [extracellular exosome] Show all	245 aa 26.7 kDa	No	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.