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FSHB

GENERAL INFORMATION

Gene name

 FSHB

Gene description

 Follicle stimulating hormone, beta polypeptide

Protein class

 Cancer-related genes
Disease related genes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Not detected
GTEx:Tissue enriched (pituitary gland)
FANTOM5:Tissue enriched (pituitary gland)

Protein evidence

 Evidence at protein level

Protein expression

 Highly expressed in anterior pituitary gland.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with external characterization data and GTEx RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA069703 , CAB023410
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Pituitary gland

Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (pituitary gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (pituitary gland)

GENE INFORMATION

Gene name

 FSHB

Synonyms

Description

 Follicle stimulating hormone, beta polypeptide (HGNC Symbol)

Entrez gene summary

 The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 p14.1

Chromosome location (bp)

 30231016 - 30235261

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000131808 (version 83.38)

Entrez gene

 2488

UniProt

 P01225 (UniProt - Evidence at protein level)

neXtProt

 NX_P01225

Antibodypedia

 FSHB antibodies

PROTEIN BROWSER
FSHB-001
FSHB-002
FSHB-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FSHB-001
ENSP00000433424
ENST00000533718
P01225 [Direct mapping]
Follitropin subunit beta
A0A0F7RQE8 [Target identity:100%; Query identity:100%]
Follicle stimulating hormone beta subunit
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Show all
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0006701 [progesterone biosynthetic process]
GO:0007165 [signal transduction]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007292 [female gamete generation]
GO:0007565 [female pregnancy]
GO:0008284 [positive regulation of cell proliferation]
GO:0016486 [peptide hormone processing]
GO:0016913 [follicle-stimulating hormone activity]
GO:0030335 [positive regulation of cell migration]
GO:0044267 [cellular protein metabolic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0070062 [extracellular exosome]
Show all
 129 aa
14.7 kDa 		Yes 0
FSHB-002
ENSP00000254122
ENST00000254122
P01225 [Direct mapping]
Follitropin subunit beta
A0A0F7RQE8 [Target identity:100%; Query identity:100%]
Follicle stimulating hormone beta subunit
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Show all
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0006701 [progesterone biosynthetic process]
GO:0007165 [signal transduction]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007292 [female gamete generation]
GO:0007565 [female pregnancy]
GO:0008284 [positive regulation of cell proliferation]
GO:0016486 [peptide hormone processing]
GO:0016913 [follicle-stimulating hormone activity]
GO:0030335 [positive regulation of cell migration]
GO:0044267 [cellular protein metabolic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0070062 [extracellular exosome]
Show all
 129 aa
14.7 kDa 		Yes 0
FSHB-003
ENSP00000416606
ENST00000417547
P01225 [Direct mapping]
Follitropin subunit beta
A0A0F7RQE8 [Target identity:100%; Query identity:100%]
Follicle stimulating hormone beta subunit
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Show all
GO:0001541 [ovarian follicle development]
GO:0005179 [hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005737 [cytoplasm]
GO:0006701 [progesterone biosynthetic process]
GO:0007165 [signal transduction]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007292 [female gamete generation]
GO:0007565 [female pregnancy]
GO:0008284 [positive regulation of cell proliferation]
GO:0016486 [peptide hormone processing]
GO:0016913 [follicle-stimulating hormone activity]
GO:0030335 [positive regulation of cell migration]
GO:0042699 [follicle-stimulating hormone signaling pathway]
GO:0044267 [cellular protein metabolic process]
GO:0045670 [regulation of osteoclast differentiation]
GO:0045780 [positive regulation of bone resorption]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0060011 [Sertoli cell proliferation]
GO:0070062 [extracellular exosome]
Show all
 129 aa
14.7 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.