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MCCC2

GENERAL INFORMATION

Gene name

 MCCC2

Gene description

 Methylcrotonoyl-CoA carboxylase 2 (beta)

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 3 antibodies.
HPA038300 , HPA038301 , HPA061546
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), liver cancer (favourable) and colorectal cancer (favourable).
Renal cancer p<0.001
Liver cancer p<0.001
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA038300
HPA038301
HPA061546

GENE INFORMATION

Gene name

 MCCC2 (HGNC Symbol)

Synonyms

 MCCB

Description

 Methylcrotonoyl-CoA carboxylase 2 (beta) (HGNC Symbol)

Entrez gene summary

 This gene encodes the small subunit of 3-methylcrotonyl-CoA carboxylase. This enzyme functions as a heterodimer and catalyzes the carboxylation of 3-methylcrotonyl-CoA to form 3-methylglutaconyl-CoA. Mutations in this gene are associated with 3-Methylcrotonylglycinuria, an autosomal recessive disorder of leucine catabolism. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q13.2

Chromosome location (bp)

 71587288 - 71658704

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000131844 (version 83.38)

Entrez gene

 64087

UniProt

 Q9HCC0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9HCC0

Antibodypedia

 MCCC2 antibodies

PROTEIN BROWSER
MCCC2-001
MCCC2-003
MCCC2-009
MCCC2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MCCC2-001
ENSP00000343657
ENST00000340941
Q9HCC0 [Direct mapping]
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial
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Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004485 [methylcrotonoyl-CoA carboxylase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0006552 [leucine catabolic process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006768 [biotin metabolic process]
GO:0009083 [branched-chain amino acid catabolic process]
GO:0015936 [coenzyme A metabolic process]
GO:0016874 [ligase activity]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0044281 [small molecule metabolic process]
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 563 aa
61.3 kDa 		No 0
MCCC2-003
ENSP00000420994
ENST00000509358
D6RDF7 [Direct mapping]
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0008152 [metabolic process]
GO:0016874 [ligase activity]
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 363 aa
39.7 kDa 		No 0
MCCC2-009
ENSP00000425474
ENST00000509539
D6RD67 [Direct mapping]
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005739 [mitochondrion]
GO:0008152 [metabolic process]
GO:0016874 [ligase activity]
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 286 aa
31.6 kDa 		No 0
MCCC2-201
ENSP00000486535
ENST00000629193
D6R9R1 [Direct mapping]
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial; Methylcrotonoyl-Coenzyme A carboxylase 2 (Beta), isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016874 [ligase activity]
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 329 aa
36.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.