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CHSY1

GENERAL INFORMATION

Gene name

 CHSY1

Gene description

 Chondroitin sulfate synthase 1

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in immune cells and smooth muscle in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining not consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Uncertain based on 1 antibody.
HPA048902
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Breast

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CHSY1 (HGNC Symbol)

Synonyms

 CSS1, KIAA0990

Description

 Chondroitin sulfate synthase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the chondroitin N-acetylgalactosaminyltransferase family. These enzymes possess dual glucuronyltransferase and galactosaminyltransferase activity and play critical roles in the biosynthesis of chondroitin sulfate, a glycosaminoglycan involved in many biological processes including cell proliferation and morphogenesis. Decreased expression of this gene may play a role in colorectal cancer, and mutations in this gene are a cause of temtamy preaxial brachydactyly syndrome. [provided by RefSeq, Dec 2011]

Chromosome

 15

Cytoband

 q26.3

Chromosome location (bp)

 101175723 - 101251932

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000131873 (version 83.38)

Entrez gene

 22856

UniProt

 Q86X52 (UniProt - Evidence at protein level)

neXtProt

 NX_Q86X52

Antibodypedia

 CHSY1 antibodies

PROTEIN BROWSER
CHSY1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CHSY1-001
ENSP00000254190
ENST00000254190
Q86X52 [Direct mapping]
Chondroitin sulfate synthase 1
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Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0002063 [chondrocyte development]
GO:0005576 [extracellular region]
GO:0005975 [carbohydrate metabolic process]
GO:0008376 [acetylgalactosaminyltransferase activity]
GO:0009954 [proximal/distal pattern formation]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016757 [transferase activity, transferring glycosyl groups]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030204 [chondroitin sulfate metabolic process]
GO:0030206 [chondroitin sulfate biosynthetic process]
GO:0030279 [negative regulation of ossification]
GO:0031667 [response to nutrient levels]
GO:0032580 [Golgi cisterna membrane]
GO:0044281 [small molecule metabolic process]
GO:0045880 [positive regulation of smoothened signaling pathway]
GO:0046872 [metal ion binding]
GO:0047238 [glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity]
GO:0050510 [N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity]
GO:0051216 [cartilage development]
GO:0051923 [sulfation]
GO:0060349 [bone morphogenesis]
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 802 aa
91.8 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.