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NR0B2

GENERAL INFORMATION

Gene name

 NR0B2

Gene description

 Nuclear receptor subfamily 0, group B, member 2

Protein class

 Disease related genes
Nuclear receptors
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (liver cancer, stomach cancer)
HPA (cell line):Cell line enriched (Hep G2)
HPA (normal tissue):Tissue enhanced (duodenum, liver)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (liver cancer, stomach cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 NR0B2 (HGNC Symbol)

Synonyms

 SHP

Description

 Nuclear receptor subfamily 0, group B, member 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p36.11

Chromosome location (bp)

 26911489 - 26913966

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000131910 (version 83.38)

Entrez gene

 8431

UniProt

 Q15466 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15466

Antibodypedia

 NR0B2 antibodies

PROTEIN BROWSER
NR0B2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NR0B2-001
ENSP00000254227
ENST00000254227
Q15466 [Direct mapping]
Nuclear receptor subfamily 0 group B member 2
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Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007219 [Notch signaling pathway]
GO:0008134 [transcription factor binding]
GO:0008203 [cholesterol metabolic process]
GO:0009749 [response to glucose]
GO:0010467 [gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0019904 [protein domain specific binding]
GO:0031100 [organ regeneration]
GO:0032024 [positive regulation of insulin secretion]
GO:0032403 [protein complex binding]
GO:0042803 [protein homodimerization activity]
GO:0042974 [retinoic acid receptor binding]
GO:0042975 [peroxisome proliferator activated receptor binding]
GO:0043234 [protein complex]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046965 [retinoid X receptor binding]
GO:0046966 [thyroid hormone receptor binding]
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 257 aa
28.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.