Expression of PODNL1 in cancer - Summary - The Human Protein Atlas

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PODNL1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PODNL1
Gene description	Podocan-like 1
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (SiHa, U-2 OS)
HPA (normal tissue):	Tissue enhanced (placenta)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA042807
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PROGNOSTIC SUMMARY
Prognostic marker in glioma (unfavourable) and urothelial cancer (unfavourable).
Glioma p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA042807

GENE INFORMATION
Gene name	PODNL1 (HGNC Symbol)
Synonyms	FLJ23447, SLRR5B
Description	Podocan-like 1 (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	p13.12
Chromosome location (bp)	13931187 - 13953392
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000132000 (version 83.38)
Entrez gene	79883
UniProt	Q6PEZ8 (UniProt - Evidence at transcript level)
neXtProt	NX_Q6PEZ8
Antibodypedia	PODNL1 antibodies

PROTEIN BROWSER

PODNL1-001	PODNL1-002	PODNL1-003	PODNL1-004	PODNL1-005	PODNL1-006	PODNL1-008	PODNL1-009	PODNL1-010	PODNL1-011	PODNL1-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PODNL1-001 ENSP00000442553 ENST00000538371	Q6PEZ8 [Direct mapping] Podocan-like protein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] Show all	510 aa 56.4 kDa	Yes	0
PODNL1-002 ENSP00000440080 ENST00000538517	Q6PEZ8 [Direct mapping] Podocan-like protein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] Show all	421 aa 46.7 kDa	Yes	0
PODNL1-003 ENSP00000345175 ENST00000339560	Q6PEZ8 [Direct mapping] Podocan-like protein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] Show all	512 aa 56.5 kDa	Yes	0
PODNL1-004 ENSP00000254320 ENST00000254320	B7Z3M0 [Direct mapping] Podocan-like protein 1; cDNA FLJ51218, weakly similar to Mus musculus podocan (Podn), mRNA Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	430 aa 47.3 kDa	No	0
PODNL1-005 ENSP00000466659 ENST00000585607	K7EMV0 [Direct mapping] Podocan-like protein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] Show all	123 aa 13.5 kDa	Yes	0
PODNL1-006 ENSP00000468151 ENST00000586075	K7ER84 [Direct mapping] Podocan-like protein 1 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	164 aa 17.8 kDa	No	0
PODNL1-008 ENSP00000468225 ENST00000591353	K7ERE6 [Direct mapping] Podocan-like protein 1 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	151 aa 16.5 kDa	No	0
PODNL1-009 ENSP00000468630 ENST00000587954	K7ESB1 [Direct mapping] Podocan-like protein 1 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	135 aa 15.1 kDa	No	0
PODNL1-010 ENSP00000464972 ENST00000588764	K7EJ07 [Direct mapping] Podocan-like protein 1 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	182 aa 20 kDa	No	0
PODNL1-011 ENSP00000467395 ENST00000588872	K7EPI2 [Direct mapping] Podocan-like protein 1 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	238 aa 26.2 kDa	No	0
PODNL1-012 ENSP00000467495 ENST00000587458	K7EPR1 [Direct mapping] Podocan-like protein 1 Show all	Predicted intracellular proteins Show all		32 aa 3.6 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.